NICHOLAS C ADAMS
Real Estate Commission in Collegeville, PA
License number
Pennsylvania RS301151
Category
Real Estate Commission
Type
Real Estate Salesperson-Standard
Address
Address
Collegeville, PA 19426
Professional information
Thiazolidinedione Derivatives As P13 Kinase Inhibitors
US Patent:
2009030, Dec 10, 2009
Filed:
Apr 11, 2007
Appl. No.:
12/296708
Inventors:
Michael Gerard Darcy - Collegeville PA, US
Steven David Knight - Collegeville PA, US
Nicholas D. Adams - Collegeville PA, US
Stanley J. Schmidt - Collegeville PA, US
Steven David Knight - Collegeville PA, US
Nicholas D. Adams - Collegeville PA, US
Stanley J. Schmidt - Collegeville PA, US
International Classification:
A61K 31/4709, C07D 417/14, A61K 31/506, A61K 31/5377, A61K 31/496, A61K 31/501, A61P 29/00, A61P 9/00, A61P 11/00
US Classification:
5142352, 546167, 544316, 544128, 544363, 544238, 514314, 514274, 51425306, 51425204
Abstract:
Invented is a method of inhibiting the activity/function of PI3 kinases using thiazolidinedione derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of thiazolidinedione derivatives.
Quinoline Derivatives As P13 Kinase Inhibitors
US Patent:
2010016, Jul 1, 2010
Filed:
May 16, 2008
Appl. No.:
12/600752
Inventors:
Nicholas D. Adams - Collegeville PA, US
Amita M. Chaudhari - Collegeville PA, US
Amita M. Chaudhari - Collegeville PA, US
Assignee:
SMITHKLINE BEECHAM CORPORATION - Philadelphia PA
International Classification:
A61K 31/5377, C07D 215/12, C07D 471/04, C07D 401/14, C07D 413/14, A61K 31/4709, A61K 31/47, A61K 31/497, A61P 35/02, A61P 35/00
US Classification:
5142352, 546176, 546118, 544363, 544128, 514314, 514303, 51425306
Abstract:
Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.
Naphthyridine, Derivatives As P13 Kinase Inhibitors
US Patent:
2010017, Jul 15, 2010
Filed:
May 29, 2008
Appl. No.:
12/602333
Inventors:
Nicholas D. Adams - Collegeville PA, US
Joelle L. Burgess - King of Prussia PA, US
Amita M. Chaudhari - Collegeville PA, US
David Knight - King of Prussia PA, US
Cynthia A. Parrish - King of Prussia PA, US
Joelle L. Burgess - King of Prussia PA, US
Amita M. Chaudhari - Collegeville PA, US
David Knight - King of Prussia PA, US
Cynthia A. Parrish - King of Prussia PA, US
International Classification:
A61K 31/4375, C07D 471/04, A61K 31/496, A61K 31/5377, A61P 37/06, A61P 29/00, A61P 37/08, A61P 9/00, A61P 11/06, A61P 1/18, A61P 13/12, A61P 17/06, A61P 25/00, A61P 25/28, A61P 9/10, A61P 35/00
US Classification:
5142345, 546122, 514300, 544362, 51425304, 544127
Abstract:
Invented is a method of inhibiting the activity/function of PI3 kinases using naphthyridine derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of naphthyridine derivatives.
Thiazolidinedione Derivatives As Pi3 Kinase Inhibitors
US Patent:
2008025, Oct 16, 2008
Filed:
Aug 24, 2007
Appl. No.:
11/844404
Inventors:
Michael Gerard Darcy - Collegeville PA, US
Steven David Knight - Collegeville PA, US
Nicholas D. Adams - Collegeville PA, US
Stanley J. Schmidt - Collegeville PA, US
Steven David Knight - Collegeville PA, US
Nicholas D. Adams - Collegeville PA, US
Stanley J. Schmidt - Collegeville PA, US
International Classification:
C07D 401/14, A61K 31/4709, A61K 31/497, A61K 31/501, C07D 413/14, A61K 31/5377, A61P 35/00
US Classification:
5142352, 51425201, 51425306, 514314, 544128, 544238, 544363, 546167
Abstract:
Invented is a method of inhibiting the activity/function of PI3 kinases using thiazolidinedione derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of thiazolidinedione derivatives.
Pyridosulfonamide Derivatives As P13 Kinase Inhibitors
US Patent:
2010031, Dec 9, 2010
Filed:
Oct 22, 2008
Appl. No.:
12/739176
Inventors:
Nicholas D. Adams - Collegeville PA, US
Michael Gerard Darcy - Collegeville PA, US
Neil W. Johnson - Collegeville PA, US
Jiri Kasparec - Collegeville PA, US
Steven David Knight - Collegeville PA, US
Kenneth Allen Newlander - Collegeville PA, US
Xin Peng - Collegeville PA, US
Lance H. Ridgers - Collegeville PA, US
Michael Gerard Darcy - Collegeville PA, US
Neil W. Johnson - Collegeville PA, US
Jiri Kasparec - Collegeville PA, US
Steven David Knight - Collegeville PA, US
Kenneth Allen Newlander - Collegeville PA, US
Xin Peng - Collegeville PA, US
Lance H. Ridgers - Collegeville PA, US
International Classification:
A61K 31/536, A61K 31/44, C07D 213/72, A61K 31/444, C07D 213/22, A61K 31/4439, C07D 401/02, A61K 31/5377, C07D 413/14, A61K 31/506, C07D 401/04, A61K 31/4709, C07D 413/02, A61K 31/498, A61P 35/00, A61P 37/06, A61P 29/00, A61P 9/00, A61P 25/00
US Classification:
5142305, 514352, 546312, 514334, 546258, 514339, 5462774, 5142355, 544124, 514274, 544316, 544310, 544333, 514256, 514341, 5462754, 546167, 514314, 514275, 544331, 544105, 514249, 544354
Abstract:
Invented is a method of inhibiting the activity/function of PI3 kinases using pyridosulfonamide derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of pyridosulfonamide derivatives.
Triazolones As Fatty Acid Synthase Inhibitors
US Patent:
2012031, Dec 13, 2012
Filed:
Feb 22, 2011
Appl. No.:
13/579040
Inventors:
Nicholas D. Adams - Collegeville PA, US
Christopher Joseph Aquino - Research Triangle Park NC, US
Amita M. Chaudhari - Collegeville PA, US
Jonathan M. Ghergurovich - Collegeville PA, US
Terence John Kiesow - Collegeville PA, US
Cynthia A. Parrish - Collegeville PA, US
Alexander Joseph Reif - Collegeville PA, US
Kenneth Wiggall - Collegeville PA, US
Christopher Joseph Aquino - Research Triangle Park NC, US
Amita M. Chaudhari - Collegeville PA, US
Jonathan M. Ghergurovich - Collegeville PA, US
Terence John Kiesow - Collegeville PA, US
Cynthia A. Parrish - Collegeville PA, US
Alexander Joseph Reif - Collegeville PA, US
Kenneth Wiggall - Collegeville PA, US
International Classification:
A61K 31/4196, C07D 471/04, A61K 31/437, C07D 401/14, A61P 35/00, C07D 403/14, A61K 31/498, A61K 31/517, C07D 413/14, A61K 31/5377, C07D 405/14, A61K 31/4709
US Classification:
51421018, 5482646, 514384, 546121, 514300, 546173, 514314, 544353, 514249, 544284, 51426623, 544132, 5142362
Abstract:
This invention relates to the use of triazolone derivatives of Formula (I) for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of triazolones in the treatment of cancer.
Fatty Acid Synthase Inhibitors
US Patent:
2013017, Jul 4, 2013
Filed:
Sep 15, 2011
Appl. No.:
13/824000
Inventors:
Nicholas D. Adams - Collegeville PA, US
Christopher Joseph Aquino - Research Triangle Park NC, US
Jonathan M. Ghergurovich - Collegeville PA, US
David Lee Musso - Raleigh NC, US
Cynthia A. Parrish - Collegeville PA, US
Christopher Joseph Aquino - Research Triangle Park NC, US
Jonathan M. Ghergurovich - Collegeville PA, US
David Lee Musso - Raleigh NC, US
Cynthia A. Parrish - Collegeville PA, US
International Classification:
C07D 471/04, C07D 413/14, C07D 405/14, C07D 401/14, C07D 403/06
US Classification:
514307, 514300, 514312, 514364, 514384, 546121, 546146, 546158, 548143, 5482632
Abstract:
This invention relates to the use of triazolone and triazolethione derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of triazolones and triazolethiones in the treatment of cancer.
Azaindole Inhibitors Of Aurora Kinases
US Patent:
7495102, Feb 24, 2009
Filed:
Sep 14, 2007
Appl. No.:
11/855183
Inventors:
Martha A. Sarpong - Collegeville PA, US
Nicholas D. Adams - Collegeville PA, US
Jeffrey Michael Axten - Collegeville PA, US
Amita M. Chaudhari - Collegeville PA, US
Dashyant Dhanak - Collegeville PA, US
Toshihiro Hamajima - Tsukuba, JP
Kenneth Allen Newlander - Collegeville PA, US
Cynthia A. Parrish - Collegeville PA, US
Jerry Leroy Adams - Collegeville PA, US
Domingos J. Silva - Collegeville PA, US
Jun Tang - Durham NC, US
Nicholas D. Adams - Collegeville PA, US
Jeffrey Michael Axten - Collegeville PA, US
Amita M. Chaudhari - Collegeville PA, US
Dashyant Dhanak - Collegeville PA, US
Toshihiro Hamajima - Tsukuba, JP
Kenneth Allen Newlander - Collegeville PA, US
Cynthia A. Parrish - Collegeville PA, US
Jerry Leroy Adams - Collegeville PA, US
Domingos J. Silva - Collegeville PA, US
Jun Tang - Durham NC, US
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
C07D 453/02
US Classification:
546133
Abstract:
The present invention relates to a compound represented by Formula (I):.
Fatty Acid Synthase Inhibitors
US Patent:
2013023, Sep 12, 2013
Filed:
Nov 7, 2011
Appl. No.:
13/883877
Inventors:
Nicholas D. Adams - Collegeville PA, US
Amita M. Chaudhari - Collegeville PA, US
Terence John Kiesow - Collegeville PA, US
Cynthia Ann Parrish - Collegeville PA, US
Alexander Joseph Reif - Collegeville PA, US
Lance Howard Ridgers - Collegeville PA, US
Stanley J. Schmidt - Collegeville PA, US
Kenneth Wiggall - Collegeville PA, US
Amita M. Chaudhari - Collegeville PA, US
Terence John Kiesow - Collegeville PA, US
Cynthia Ann Parrish - Collegeville PA, US
Alexander Joseph Reif - Collegeville PA, US
Lance Howard Ridgers - Collegeville PA, US
Stanley J. Schmidt - Collegeville PA, US
Kenneth Wiggall - Collegeville PA, US
International Classification:
C07D 498/10, A61K 45/06, A61K 31/499, A61K 31/4709, A61K 31/5386, C07D 471/10
US Classification:
5142308, 544 71, 544231, 51425306, 546 16, 514278
Abstract:
This invention relates to the use of spirocyclic piperidine derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of spirocyclic piperidines in the treatment of cancer.
Compounds, Compositions, And Methods
US Patent:
2008017, Jul 24, 2008
Filed:
Apr 13, 2006
Appl. No.:
11/910731
Inventors:
Nicholas D. Adams - Collegeville PA, US
Michael Gerard Darcy - Collegeville PA, US
Dashyant Dhanak - Collegeville PA, US
Kevin J. Duffy - Collegeville PA, US
Duke M. Fitch - Collegeville PA, US
Steven David Knight - Collegeville PA, US
Kenneth Allen Newlander - Collegeville PA, US
Antony N. Shaw - Collegeville PA, US
Michael Gerard Darcy - Collegeville PA, US
Dashyant Dhanak - Collegeville PA, US
Kevin J. Duffy - Collegeville PA, US
Duke M. Fitch - Collegeville PA, US
Steven David Knight - Collegeville PA, US
Kenneth Allen Newlander - Collegeville PA, US
Antony N. Shaw - Collegeville PA, US
International Classification:
A61K 31/551, C07D 285/16, A61K 31/549, C07D 311/76, A61K 31/352, A61K 31/498, A61P 35/04, A61P 37/00, A61P 29/00, A61P 9/00, C07D 281/10, C07D 239/80, C07D 215/00, A61K 31/47, C07D 243/10
US Classification:
51421105, 544 11, 5142228, 549399, 514457, 546158, 514312, 540500, 544286, 51426631, 540490
Abstract:
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.