NIAN LIU
Pilots at Keystone Ct, Edison, NJ
License number
New Jersey C1051693
Issued Date
May 2016
Expiration Date
May 2017
Category
Airmen
Address
Address
81 Keystone Ct, Edison, NJ 08817
Professional information
Benzimidazole And Pyridylimidazole Derivatives
US Patent:
7300945, Nov 27, 2007
Filed:
Jul 12, 2005
Appl. No.:
11/179458
Inventors:
Guiying Li - Branford CT, US
Pamela Albaugh - Carlsbad CA, US
Kevin S. Currie - North Branford CT, US
Guolin Cai - Thousand Oaks CA, US
Linda M. Gustavson - Ringoes NJ, US
Kyungae Lee - Newton MA, US
Alan Hutchison - Madison CT, US
George D. Maynard - Clinton CT, US
Jun Yuan - Guilford CT, US
Ling Hong Xie - Guilford CT, US
Manuka Ghosh - Madison CT, US
Nian Liu - Edison NJ, US
George P. Luke - Clinton CT, US
Scott Mitchell - East Haven CT, US
Martin Patrick Allen - North Stonington CT, US
Spiros Liras - Stonington CT, US
Pamela Albaugh - Carlsbad CA, US
Kevin S. Currie - North Branford CT, US
Guolin Cai - Thousand Oaks CA, US
Linda M. Gustavson - Ringoes NJ, US
Kyungae Lee - Newton MA, US
Alan Hutchison - Madison CT, US
George D. Maynard - Clinton CT, US
Jun Yuan - Guilford CT, US
Ling Hong Xie - Guilford CT, US
Manuka Ghosh - Madison CT, US
Nian Liu - Edison NJ, US
George P. Luke - Clinton CT, US
Scott Mitchell - East Haven CT, US
Martin Patrick Allen - North Stonington CT, US
Spiros Liras - Stonington CT, US
Assignee:
Neurogen Corporation - Branford CT
International Classification:
C07D 471/04, A61K 31/437
US Classification:
514303, 546118, 206570
Abstract:
This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula IThe invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAreceptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAreceptors in tissue sections.
3-Substituted-6-Aryl Pyridines
US Patent:
2011028, Nov 17, 2011
Filed:
Jan 3, 2011
Appl. No.:
12/983661
Inventors:
Alan J. Hutchinson - Madison CT, US
Jun Yuan - Guilford CT, US
Kyungae Lee - Newton MA, US
George D. Maynard - Clinton CT, US
Bertrand L. Chenard - Waterford CT, US
Nian Liu - Edison NJ, US
Qin Guo - Waterford CT, US
Zihong Guo - Waterford CT, US
Peter Hrnciar - Hamden CT, US
Jun Yuan - Guilford CT, US
Kyungae Lee - Newton MA, US
George D. Maynard - Clinton CT, US
Bertrand L. Chenard - Waterford CT, US
Nian Liu - Edison NJ, US
Qin Guo - Waterford CT, US
Zihong Guo - Waterford CT, US
Peter Hrnciar - Hamden CT, US
International Classification:
A61K 31/397, A61K 31/5377, A61K 31/4439, A61K 31/4709, C12N 5/078, A61P 19/02, A61P 17/06, A61P 9/00, A61P 11/06, C12N 5/071, A61K 31/4418, A61K 31/4545
US Classification:
5142102, 514356, 514350, 514345, 5142355, 514357, 514339, 514314, 514318, 435375
Abstract:
3-substituted-6-aryl pyridines of Formula I are provided:wherein R, R, R, R, R, A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 3-substituted-6-aryl pyridines, which are useful as probes for the localization of C5a receptors.
3-Substituted-6-Aryl Pyridines
US Patent:
7863454, Jan 4, 2011
Filed:
Mar 3, 2008
Appl. No.:
12/041038
Inventors:
Alan J. Hutchison - Madison CT, US
Jun Yuan - Guilford CT, US
Kyungae Lee - Guilford CT, US
George D. Maynard - Clinton CT, US
Bertrand L. Chenard - Waterford CT, US
Nian Liu - Edison NJ, US
Qin Guo - Branford CT, US
Zihong Guo - Southbury CT, US
Peter Hrnciar - Hamden CT, US
Jun Yuan - Guilford CT, US
Kyungae Lee - Guilford CT, US
George D. Maynard - Clinton CT, US
Bertrand L. Chenard - Waterford CT, US
Nian Liu - Edison NJ, US
Qin Guo - Branford CT, US
Zihong Guo - Southbury CT, US
Peter Hrnciar - Hamden CT, US
Assignee:
Novartis International Pharmaceutical Ltd. - Hamilton
International Classification:
C07D 401/04
US Classification:
5462757
Abstract:
3-substituted-6-aryl pyridines of Formula I are provided:.
3-Substituted-6-Aryl Pyridines
US Patent:
7342115, Mar 11, 2008
Filed:
Nov 7, 2003
Appl. No.:
10/704364
Inventors:
Alan J. Hutchison - Madison CT, US
Jun Yuan - Guilford CT, US
Kyungae Lee - Guilford CT, US
George D. Maynard - Clinton CT, US
Bertrand L. Chenard - Waterford CT, US
Nian Liu - Edison NJ, US
Qin Guo - Branford CT, US
Zihong Guo - Southbury CT, US
Peter Hrnciar - Hamden CT, US
Jun Yuan - Guilford CT, US
Kyungae Lee - Guilford CT, US
George D. Maynard - Clinton CT, US
Bertrand L. Chenard - Waterford CT, US
Nian Liu - Edison NJ, US
Qin Guo - Branford CT, US
Zihong Guo - Southbury CT, US
Peter Hrnciar - Hamden CT, US
Assignee:
Neurogen Corporation - Branford CT
International Classification:
C07D 213/61, C07D 213/62, C07D 213/72, C07D 213/73, C07D 213/84
US Classification:
546301, 546286, 546287, 546288, 546289, 546290, 546294, 546295, 546296, 546297, 546298, 546300, 546302, 546303, 546304, 546307, 546310, 546311, 546312, 546314, 546326, 546329, 546330, 546334, 546335, 546337, 546339, 546340
Abstract:
3-substituted-6-aryl pyridines of Formula I are provided:.