Inventors:
David Cohen - Chestnut Hill MA, US
Neil Wagle - Brookline MA, US
Gregory D. Cuny - Cambridge MA, US
Jun Xian - Sharon MA, US
Marcie Glicksman - Winchester MA, US
Ross L. Stein - Cambridge MA, US
Ekaterina Y. Shishova - Bryn Mawr PA, US
Assignee:
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA
International Classification:
A61K 31/505, A61K 31/44, A61K 31/472, C07C 335/26, A61K 31/17, C07D 295/155, A61K 31/5377, A61P 3/04, A61P 3/10, A61P 1/16, A61P 11/06, A61P 9/12, A61P 3/06, A61P 9/00, A61P 19/02, A61P 9/10, A61P 25/00, A61P 25/24, A61P 35/00, A61P 1/04, C07D 239/69
US Classification:
5142382, 544297, 514275, 514346, 514309, 564 23, 514584, 544160
Abstract:
This invention relates to compounds of Formulas I, II, and III, and their use as inhibitors of phosphatidylcholine transfer protein (PC-TP). The invention further relates to pharmaceutical compositions and methods of treatment of disorders related to the inhibition of PC-TP using the compounds of Formulas I, II, and III. Such disorders include obesity and disorders associated with obesity.