Inventors:
Charles L. Sawyers - Los Angeles CA, US
Michael Burgess - Los Angeles CA, US
Neil Pravin Shah - Los Angeles CA, US
Francis Y. Lee - Yardley PA, US
John S. Tokarski - Princeton NJ, US
Herbert E. Klei - Lawrenceville NJ, US
International Classification:
A61K 31/497, C12Q 1/48, G01N 33/53, C12Q 1/68
US Classification:
51425219, 435 15, 435 71, 435 6
Abstract:
The present invention relates to mutant BCR-ABL kinase proteins, and to diagnostic and therapeutic methods and compositions useful in the management of disorders, for example cancers, involving cells that express such mutant BCR-ABL kinase proteins.