Inventors:
Ross G. Clark - Pacifica CA
Neil Gesundheit - Palo Alto CA
Marc R. Hammerman - St. Louis MO
Steven B. Miller - St. Louis MO
Assignee:
Genentech, Inc. - South San Francisco CA
Washington University - St. Louis MO
International Classification:
A61K 3800, A61K 3827
Abstract:
A method is disclosed that comprises administering insulin-like growth factor-I (IGF-I) to a mammal so as to sustain its biological activity in the mammal comprising administering a therapeutically effective amount of IGF-I to the mammal to provide an exposure to IGF-I for a period of time that stimulates the maximum biological response in the mammal, then discontinuing said administration for a period of time equal to or less than the time period used for administration, and repeating this pattern of administration and discontinuance of administration for a period as long as necessary to achieve or maintain the desired biological response in the mammal.