Inventors:
Neil Cary Josephson - Seattle WA, US
International Classification:
A61K 38/20, A61K 39/00, A61K 38/37, A61P 37/06, A61P 7/04
Abstract:
This invention relates to methods and compositions for suppressing an immune response to Factor VIII in subjects suffering from hemophilia A and having preformed inhibitor antibodies against Factor VIII, and compositions and methods that advantageously render subjects amenable to standard treatments for hemophilia A, including Factor VIII replacement therapy.