NEENA AGARWALA
Medical Practice in State College, PA
License number
Pennsylvania MD071087L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
State College, PA 16801
Professional information
Pharmaceutical Composition For Drugs Subject To Supercooling
US Patent:
5082655, Jan 21, 1992
Filed:
Feb 17, 1989
Appl. No.:
7/311960
Inventors:
Wallace C. Snipes - Pine Grove Mills PA
Neena Agarwala - University Park PA
Neena Agarwala - University Park PA
Assignee:
Zetachron, Inc. - State College PA
International Classification:
A61K 3174, A61K 922, A01N 2508, A01N 2534
US Classification:
424386
Abstract:
A sustained release composition for releasing a biologically active compound into an aqueous liquid environment comprises a biologically active compound dispersed in a matrix which progressively erodes in contact with a liquid environment, the matrix having a melting point below the melting point of the biologically active compound, and the matrix comprising a mixture of
a. ) 5% to 100% by weight of a solid water-dispersible polyether diol having a molecular weight from about 1000 to about 20,000, selected from the group consisting of polyethylene glycols and polyethylene oxide-polypropylene oxide block copolymers, and
b. ) 95 to 0% by weight of an erosion rate modifier which is an amphiphilic compound insoluble in the aqueous liquid.
Dosage forms comprising the sustained release composition are prepared by molding, particularly by injection molding.