NEAL C BROWN
Veterinary in Greenfield, NH
License number
Massachusetts 1389
Issued Date
Aug 1, 1962
Expiration Date
Feb 28, 2006
Type
Veterinarian
Address
Address
Greenfield, NH 03047
Professional information
Purine And Isosteric Antibacterial Compounds
US Patent:
6926763, Aug 9, 2005
Filed:
Feb 10, 2003
Appl. No.:
10/364024
Inventors:
George E. Wright - Worcester MA, US
Wei-Chu Xu - Worcester MA, US
Neal C. Brown - Greenfield NH, US
Wei-Chu Xu - Worcester MA, US
Neal C. Brown - Greenfield NH, US
Assignee:
GLSynthesis, Inc. - Worcester MA
International Classification:
C07D473/18, A61K031/522, A61P031/04, C09D005/14
US Classification:
106 1832, 544276, 544118, 5142342, 5142632, 51426337
Abstract:
The invention features compounds of the formula:
or a pharmaceutically acceptable salt thereof, wherein A is CRand B is N; wherein n is 0-3; wherein Ris (CH)—{(G)—(CH)}—L, in which G is CH, CH═CH, C≡C, CO, O, S, or NR, where Ris H or Calkyl, CHR, where Ris OH or Calkyl, CH(CRR), where each of Rand Ris, independently, H, halo, or Calkyl, OCO, CONR, NRCO, where each of Rand Ris, independently, H or Calkyl, SONH, or NHSO; in which m is 1-4, o is 0-4, p is 0-4, and q is 0-4. The compounds disclosed herein have potent anti-microbial, e. g. , both Gram-positive and Gram-negative anti-bacterial properties. The compounds inhibit DNA polymerase IIIC and DNA polymerase IIIE enzymes and thus act therapeutically by inhibiting the growth of a broad array of bacteria. The compounds can be administered to prevent or to treat Gram-positive or Gram-negative bacterial infections, e. g. , in eukaryotic cell cultures, animals, or humans.
N3-Substituted 6-Anilinopyrimidines And Methods To Treat-Gram-Positive Bacterial And Mycoplasmal Infections
US Patent:
2003011, Jun 19, 2003
Filed:
Jun 17, 2002
Appl. No.:
10/174131
Inventors:
Chengxin Zhi - Worcester MA, US
Zheng-Yu Long - Worcester MA, US
George Wright - Worcester MA, US
Neal Brown - Greenfield NH, US
Serge Lamothe - Boisbriand, CA
Irina Motorina - Laval, CA
Zheng-Yu Long - Worcester MA, US
George Wright - Worcester MA, US
Neal Brown - Greenfield NH, US
Serge Lamothe - Boisbriand, CA
Irina Motorina - Laval, CA
International Classification:
A61K031/541, A61K031/5377, A61K031/513, C07D417/02, C 07D 4 3/02, C07D413/02
US Classification:
514/227800, 514/252140, 514/269000, 514/235800, 544/060000, 544/295000, 544/311000, 544/123000
Abstract:
Compounds useful for treating Gram-positive bacterial and mycoplasmal infections are disclosed. The compounds have the general formulae shown below.