Inventors:
Nauder Faraday - Towson MD, US
Assignee:
The John Hopkins University - Baltimore MD
International Classification:
A61K 39/395, A61K 31/196, A61K 31/407, A61K 31/58, A61K 31/708, A61K 31/7088, A61K 38/02, A61K 38/06, A61K 38/07, A61K 38/16, A61K 38/10, A61K 31/365, C12Q 1/37, C12Q 1/02, A61P 7/02, A61P 9/10, A61P 9/00
US Classification:
4241331, 514563, 514411, 514172, 514 47, 4241581, 514 44 R, 514 138, 514 137, 514468, 435 23, 435 29
Abstract:
The instant invention provides methods and compositions for the treatment, prevention and diagnosis of for example, platelet aggregation or clot formation in a subject. The invention inhibits the activity of decreases the amount of neutrophils in the subject by inhibiting the activity or production of IL-6, interferon-gamma, STAT1, or cathepsin D. The invention addresses decreasing the amount of neutrophils in an attempt to treat subjects that have or are at risk of developing a vascular occlusive disease, an ischemia or reperfusion injury, an acute or chronic inflammatory state, autoimmune disease, myelodysplastic syndrome, tissue injury from surgery or accidental trauma, acute bacterial or viral infection, has undergone a microvascular surgical reconstructive procedure, is receiving granulocyte colony stimulating factor therapy, receiving stem cell therapy, or has sickle cell anemia.