Inventors:
Nathan Rabinovitch - Denver CO, US
Erwin Gelfand - Englewood CO, US
International Classification:
A61K 31/47, A61K 31/404, A61K 31/41, A61K 31/381, G01N 33/92
US Classification:
514311, 514415, 514382, 514443, 436 71
Abstract:
The present invention provides a method of determining the susceptibility of a subject to treatment with a leukotriene modifier by determining the subject's cysteinyl leukotriene (CysLT) level and the subject's level of eosinophilic airway inflammation and identifying a subject with a high ratio of CysLT levels to eosinophilic airway inflammation as susceptible to treatment with the leukotriene modifier. Also discussed is a method of treatment of subjects who are susceptible to treatment that includes administering a leukotriene modifier to such a subject.