Inventors:
Peter M. Elias - Mill Valley CA
Nathan N. Bass - San Francisco CA
Karen Hanley - Mill Valley CA
Kenneth R. Feingold - San Rafael CA
Assignee:
The Regents of the University of California - Oaklland CA
International Classification:
A61K 3120
Abstract:
Disorders of the skin and mucous membrane that have a disrupted or dysfunctional epidermal barrier are treated or prevented by topical application of compounds that are either activators of the farnesoid X receptor, activators of the peroxisome proliferator-activated receptor , and oxysterol activators of the LXR receptor. The same compounds are also effective in treating disorders of epidermal differentiation and proliferation.