DR. NATHAN G ROTH, DDS
Dentist at Lombard St, San Francisco, CA

5985324, Nov 16, 1999

May 7, 1998

9/073982

Patrick S.-L. Wong - Burlingame CA
Vincent J. Ferrari - Foster City CA
Jeffrey W. Etter - Castro Valley CA
Miriam A. Martin - Los Altos CA
Nathan Roth - San Francisco CA
Christopher M. G. Ohms - San Mateo CA
Andrew I. Poutiatine - Menlo Park CA
James Horvath - San Jose CA

ALZA Corporation - Palo Alto CA

A61K 924

424473

The present invention is directed to an oral active agent delivery system comprising improved flow controllers. A hollow tubular member (10) containing the active agent formulation and having a fluid passing controller (14) is placed at one end (16) into a fluid and at a second end (18) into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.

6224908, May 1, 2001

May 24, 2000

9/577041

Patrick S.-L. Wong - Burlingame CA
Vincent J. Ferrari - Foster City CA
Jeffrey W. Etter - Castro Valley CA
Miriam A. Martin - Los Altos CA
Nathan Roth - San Francisco CA
Christopher M. G. Ohms - San Mateo CA
Andrew I. Poutiatine - Menlo Park CA
James Horvath - San Jose CA

Alza Corporation - Mountain View CA

A61K 924

424473

Oral active agent delivery system having improved flow controllers. A hollow tubular member containing the active agent formulation and having a fluid passing controller is placed at one end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.

5288289, Feb 22, 1994

May 12, 1992

7/881909

Ronald P. Haak - San Jose CA
J. Richard Gyory - San Jose CA
Felix Theeuwes - Los Altos CA
Felix A. Landrau - San Jose CA
Nathan Roth - San Francisco CA
Robert M. Myers - Stanford CA

ALZA Corporation - Palo Alto CA

A61N 130

604 20

A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21,22). Alternatively, the liquid can be released from the pouches (21,22) using pouch piercing pins (36,37). The liquid released from the pouches (21,22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31,32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27,28) are provided to carry the liquid from the gel layers (31,32) to the drug and electrolyte layers (15, 16).

5158537, Oct 27, 1992

Oct 29, 1990

7/605046

Ronald P. Haak - San Jose CA
J. Richard Gyory - San Jose CA
Felix Theeuwes - Los Altos CA
Felix A. Landrau - San Jose CA
Nathan Roth - San Francisco CA
Robert M. Myers - Stanford CA

Alza Corporation - Palo Alto CA

A61N 130

604 20

A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21, 22). Alternatively, the liquid can be released from the pouches (21, 22) using pouch piercing pins (36, 37). The liquid released from the pouches (21, 22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31, 32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27, 28) are provided to carry the liquid from the gel layers (31, 32) to the drug and electrolyte layers (15, 16).

4828109, May 9, 1989

Jun 20, 1988

7/209234

Nathan Roth - San Francisco CA
Andrew Nelsen - Palo Alto CA

ALZA Corporation - Palo Alto CA

B65D 7300

206388

The package of the present invention comprises a sheath formed from a folded, relatively rigid strip having structure for receiving and releasably holding the ends of the fiber to be packaged. In a preferred embodiment, the fiber is between the two folded over parts of the strip with the ends of the fiber anchored in place in a pair of slits. The sheath is in a pouch formed by a pair of foil members on opposite sides of the sheath. When ready for use, the package is opened by peeling the foil members apart, thereby exposing the sheath and permitting access to the fiber carried by the sheath. An improved apparatus and method are provided to form the package. In the first instance, the sheath is prepared by first folding a strip of relatively rigid material, such as siliconized polyester, the moving the folded strip along a path of travel and feeding the fiber into the region between the parts of the strip as the strip moves. At a certain location along the path of the strip, the fiber is forced into each slit of the strip and the fiber becomes releasably attached to the strip. At another location, the strip is cut; thus, in this way, a plurality of sheaths with fiber lengths between the sides of the sheaths are formed and are immediately moved to a location where the foil members are applied to the opposite sides of the sheaths.

4111302, Sep 5, 1978

Nov 22, 1976

5/743617

Nathan Roth - San Francisco CA

Alza Corporation - Palo Alto CA

B65D 8310

206363

A package for an intrauterine device-intrauterine device inserter combination and a "pillow pack" carton for the package are disclosed. The package consists of three elements: (1) a thermoformed plastic tray having an elongated, relatively deep cavity for holding the combination, a convexly curved marginal ledge about the cavity, an end wall extending downwardly from each end of the ledge, and a flange extending outwardly from the bottom of each end wall; (2) a cover that fits over the cavity and has the same curvature as the marginal ledge; and (3) an adhesive coating on the inner side of the cover by which the cover is attached to the ledge over the cavity. The package is enveloped in a paper carton that has a bottom wall on which the package bottom rests, a pair of end walls, each of which has an inwardly extending section that overlies one of the flanges of the package tray whereby the package is held firmly in place, and a pair of flaps that are foldably connected to the longitudinal edges of the bottom wall and fold over the top of the package in an overlapping, interlocking fashion.

4828108, May 9, 1989

Jun 20, 1988

7/209233

Nathan Roth - San Francisco CA
Andrew Nelsen - Palo Alto CA

ALZA Corporation - Palo Alto CA

B65D 7300

206388

The package of the present invention comprises a sheath formed from a folded, relatively rigid strip having structure for receiving and releasably holding the ends of the fiber to be packaged. In a preferred embodiment, the fiber is between the two folded over parts of the strip with the ends of the fiber anchored in place in a pair of slits. The sheath is in a pouch formed by a pair of foil members on opposite sides of the sheath. When ready for use, the package is opened by peeling the foil members apart, thereby exposing the sheath and permitting access to the fiber carried by the sheath. An improved apparatus and method are provided to form the package. In the first instance, the sheath is prepared by first folding a strip of relatively rigid material, such as siliconized polyester, then moving the folded strip along a path of travel and feeding the fiber into the region between the parts of the strip as the strip moves. At a certain location along the path of the strip, the fiber is forced into each slit of the strip and the fiber becomes releasably attached to the strip. At another location, the strip is cut; thus, in this way, a plurality of sheaths with fiber lengths between the sides of the sheaths are formed and are immediately moved to a location where the foil members are applied to the opposite sides of the sheaths.

6106845, Aug 22, 2000

Apr 27, 1999

9/299740

Howard B. Rosen - Los Gatos CA
Nathan Roth - San Francisco CA
Phyllis I. Gardner - Stanford CA

ALZA Corporation - Mountain View CA

A61K 900, A61K 924

424400

The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber containing the active agent formulation and having a fluid passing active agent formulation retainer is placed at a first end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the second end of the chamber.

5268209, Dec 7, 1993

Oct 21, 1991

7/779682

James A. Hunt - Fremont CA
James L. Osborne - Mountain View CA
John T. Dunn - Redwood City CA
Melinda K. Nelson - Sunnyvale CA
Nathan Roth - San Francisco CA

Alza Corporation - Palo Alto CA

B65D 3008

428 343

The invention herein pertains to methods and materials for producing a nicotine maintenance pouch. Laminates comprising a nicotine barrier layer and a nicotine degradation agent barrier layer are disclosed. In a preferred embodiment, the nicotine barrier layer comprises a nitrile rubber modified acrylonitrilemethyl acrylate copolymer. An especially preferred nicotine barrier material comprises, by weight percent, 75% acrylonitrile, and 25% methyl acrylate with 10% butadiene (AN-MA/B). The nicotine degradation agent barrier layer is preferably aluminum foil. In an especially preferred embodiment, the laminate comprises a layer of AN-MA/B adhered to a layer of aluminum foil, which in turn is adhered to a layer of paper stock. Pouches comprising a self-sealed nicotine barrier layer and a nicotine degradation agent barrier layer are disclosed. These pouches are preferably formed from the laminates above.