DR. NARDO ZAIAS, M.D.
Medical Practice at Alton Rd, Miami, FL

5766214, Jun 16, 1998

Apr 18, 1996

8/634569

Thomas L. Mehl - Newberry FL
Nardo Zaias - Miami Beach FL

A45D 2600

606 9

A method of permanent hair removal which uses a high energy light source projected at the skin to cause death of the hair follicle by photothermolysis. The process uses either incoherent or coherent light energy. Additional melanin is added to the skin by a process which delivers the melanin to the region of the hair follicle thereby enhancing that area as a light absorbing target. Collateral damage to the surrounding skin tissue is minimized. The delivery process uses liposomes selected particularly to encapsulate and carry melanin to the target region. The invention also encompasses a general method of deleterious tissue destruction by selective introduction of melanin and subsequent photothermolysis.

5059192, Oct 22, 1991

Apr 24, 1990

7/513850

Nardo Zaias - Miami Beach FL

A61N 500

606 9

A method of depilation using a ruby red laser includes supplying optimum energy to a selected area of skin to cause follicular injury to the extent that depilation occurs without epidermal scaring.

8052984, Nov 8, 2011

Feb 5, 2008

12/012647

Pichit Suvanprakorn - Bangkok, TH
Panida Vayumhasuwan - Bangkok, TH
Nardo Zaias - Miami Beach FL, US

Biophile Corporation, Ltd. - Lumpinee, Patumwan Bangkok

A61K 31/137, A61K 31/685, A61K 47/24, A61K 9/00, A61P 31/10, A61K 8/02, A61K 8/41, A61Q 3/00, A01N 25/04, A01N 25/30, A01N 33/04

424405, 424 61, 514 78, 514655, 514772, 514944, 514946, 514947, 514975

The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages. The allylamine active ingredient is prepared in an acidic environment; the acidic environment altering the physiochemical properties of the active ingredient resulting in the active ingredient having a positive charge. The positive charge and enhancers used in the formula allow for increased penetration of the active ingredient through skin and skin appendages. The positively charged active ingredients are either dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle. The bead structure minimizes the molecular diffusion of the positively charged active ingredient and a catalytic species through the bead structure, thus stabilizes the positively charged active ingredient inside the bead by impeding the interaction of the positively charged active ingredient and the catalytic species, and thereby extending the shelf life of the positively charged active ingredient.

2012008, Apr 12, 2012

Oct 4, 2011

13/252796

Pichit Suvanprakorn - Bangkok, TH
Panida Vayumhasuwan - Bangkok, TH
Nardo Zaias - Miami Beach FL, US

A61K 31/137, A61P 31/10, A61K 9/50, A61K 9/127, B82Y 5/00

424450, 514655, 424490, 977773, 977906, 977907

The present invention provides compositions comprising allylamine drug compounds for topical treatment of fungal infections of the skin and skin appendages. In some embodiments a positive charge and enhancers are used in the compositions to allow for increased penetration of the active ingredient through skin and skin appendages. In some embodiments the positively charged active ingredients are either dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle. The present invention also provides methods for making compositions comprising an allylamine drug compound, and methods of using such compositions for the treatment of fungal infections of the skin and skin appendages.

5411741, May 2, 1995

Jul 29, 1993

8/099491

Nardo Zaias - Miami Beach FL

A61K 9127

424450

The present invention relates to a composition and method for skin depigmentation comprising the steps of encapsulating an effective amount of a water-soluble melanin inhibiting compound with a liposome, suspending the encapsulated melanin inhibiting compound within a topical vehicle, topically applying to the epidermis of the skin the suspended and encapsulated melanin inhibiting compound whereby the liposomes are transdermally delivered to the basal cell region of the epidermis causing interference with the biochemical synthesis of melanin in situ and subsequent depigmentation of the skin.

2003006, Apr 10, 2003

Oct 3, 2002

10/264205

Pichit Suvanprakorn - Bangkok, TH
Tanusin Ploysangam - Bangkok, TH
Lerson Tanasugarn - Bangkok, TH
Suwalee Chandrkrachang - Bangkok, TH
Nardo Zaias - Miami Beach FL, US

A61K009/127, A61K035/78

424/450000, 424/725000

Compositions and methods for administration of active agents encapsulated within liposome beads to enable a wider range of delivery vehicles, to provide longer product shelf-life, to allow multiple active agents within the composition, to allow the controlled use of the active agents, to provide protected and designable release features and to provide visual inspection for damage and inconsistency.

2004022, Nov 11, 2004

Jun 9, 2004

10/864149

Pichit Suvanprakorn - Bangkok, TH
Tanusin Ploysangam - Bangkok, TH
Lerson Tanasugarn - Bangkok, TH
Suwalee Chandrkrachang - Bangkok, TH
Nardo Zaias - Miami Beach FL, US

A61K009/127, A61K009/14

424/450000, 424/489000

A topical application and methods for administration of active agents encapsulated within non-permeable macro-beads to enable a wider range of delivery vehicles, to provide longer product shelf-life, to allow multiple active agents within the composition, to allow the controlled use of the active agents, to provide protected and designable release features and to provide visual inspection for damage and inconsistency.

5131417, Jul 21, 1992

Nov 14, 1991

7/791674

Nardo Zaias - Miami Beach FL
Syed Pervaiz - Miami FL

A45D 704

132204

A method of obtaining a hair damage rating is obtained by determining the change in hair structure, such as measuring the amount of free sulfhydryl groups after hair treatment or exposure to agents, comparing this with a number of such groups before treatment to obtain a percentage change, establishing a rating scale having a range of percentage change values, and selecting the hair damage factor a number corresponding to the determined percentage change after treatment.