Inventors:
Carole Young - Miami FL
Michael Elliott - Cooper FL
Nancy Naylor - Waverly PA
Timothy J. Fischer - Raleigh NC
Assignee:
Coulter Corporation - Miami FL
International Classification:
G01N 3100
US Classification:
436 10, 436 13, 436 15, 436 16, 436 17, 436 18, 436 63, 424532, 424533, 424534
Abstract:
A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sample is analyzed. Alternatively, the spatial position of a statistically significant number of patient blood samples can be used. The method enables the monitoring of an instrument for problems associated with debris and noise caused by red cell lysis inefficiency; instrument reagents pump volume settings; instrument laser alignments; instrument gain settings; and flow noise caused by partial plugs, residual plugs or other flow problems. The method provides a more specific indication of the type and cause of an instrument malfunctioning than non specific flagging provided by prior art methods.