NANCY E LEE
Broker in Brookline, MA
License number
Massachusetts 59286
Issued Date
Jan 1, 1985
Expiration Date
Nov 5, 1987
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Salesperson
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Address
Brookline, MA 02416
Professional information
Catalytic Asymmetric Reduction Of Trisubstituted Olefins
US Patent:
5491233, Feb 13, 1996
Filed:
Jul 12, 1994
Appl. No.:
8/273842
Inventors:
Stephen L. Buchwald - Somerville MA
Richard D. Broene - Brunswick ME
Nancy E. Lee - Brookline MA
Richard D. Broene - Brunswick ME
Nancy E. Lee - Brookline MA
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C07D26530, C07D20746, C07C20900, C07C 4302, C07C 2100
US Classification:
544174
Abstract:
A catalytic asymmetric reduction process, which, by hydrogenating trisubstituted olefins, yields a corresponding organic compound having a high level of enantiomeric purity is disclosed. The process is also effective for the catalytic asymmetric reduction of certain enamines and related compounds to yield a corresponding amine or related compound, respectively, having a high level of enantiomeric purity. The reduction process utilizes a chiral metal catalyst that includes a metal or metal complex that is selected from groups 3, 4, 5, or 6, lanthanides and actinides. Moreover, the process uses hydrogen as the stoichiometric reducing agent and may be carried out at pressures ranging from about 0. 5 to 200 atmospheres. The reaction can also be carried out using an acidic compound as a rate enhancing additive.
Catalytic Asymmetric Reduction Of Enamines
US Patent:
5489682, Feb 6, 1996
Filed:
Feb 10, 1994
Appl. No.:
8/195358
Inventors:
Stephen L. Buchwald - Somerville MA
Nancy E. Lee - Brookline MA
Nancy E. Lee - Brookline MA
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C07D20702, C07D20706, C07D30702, C07C20940, C07C20952
US Classification:
544106
Abstract:
A catalytic asymmetric reduction process, which, by hydrogenating enamines, yields a corresponding amine having a high level of enantiomeric purity is disclosed. The reduction process utilizes a chiral metal catalyst that includes a metal or metal complex that is selected from groups 3, 4, 5, or 6, lanthanides and actinides. Moreover, the process uses hydrogen as the stoichiometric reducing agent and may be carried out at pressures ranging from about 0. 5 to 200 atmospheres.