Inventors:
Malcolm Brenner - Houston TX, US
Gianpietro Dotti - Houston TX, US
Nabil Ahmed - Houston TX, US
Claudia Rossig - Heidelberg, DE
Stephen M.G. Gottschalk - Houston TX, US
Zakaria Grada - Houston TX, US
International Classification:
C12N 5/0783, C07K 16/18
US Classification:
4241781, 424 9321, 435375
Abstract:
The present invention concerns immunotherapy for cancers having cells that comprise the ganglioside GD2 antigen. In specific embodiment, T cells having a chimeric receptor that targets GD2 is employed. In particular cases, the chimeric receptor comprises antibody, cytoplasmic signaling domain from the T cell receptor, and/or costimulatory molecule(s).