Inventors:
Josep M. Llovet - New York NY, US
Scott L. Friedman - Scarsdale NY, US
Myron Schwartz - New York NY, US
Assignee:
Mount Sinai School of Medicine - New York NY
International Classification:
C12Q 1/68, G01N 33/50
Abstract:
Methods and compositions are provide to allow discrimination of dysplastic nodules from early HCC nodules. More specifically, it has been determined that TERT, GPC3, gankyrin, survivin, TOP2A, LYVE1, Ecadherin, IGFBP3, PDGFRA, TGFA, cyclin D1 and HGF are differentially expressed in HCC as compared to normal liver cells and liver cells that have dysplastic, non-cancerous nodules.