Inventors:
Moti L. Kashyap - Rancho Palos Verdes CA, US
Shobha V. Kamanna - Irvine CA, US
Vaijinath S. Kamanna - Irvine CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 31/455, A61K 45/06, C07D 213/80
US Classification:
51425506, 514356, 514355, 514350, 514473, 514332, 514277, 514247, 546318
Abstract:
Niacin prevents and/or reverses the development of experimental hepatic steatosis, deposition of triglycerides in liver and serum of individuals, deposition of total cholesterol in liver and serum in individuals, and inhibit liver lipid peroxidation and oxidative stress in individuals at risk of developing fatty liver disease or NAFLD. In cultured human hepatocytes, niacin inhibits alcohol-induced fat accumulation.