Inventors:
Nicholas J. Donato - Ann Arbor MI, US
Christiane Wobus - Dexter MI, US
Hollis D. Showalter - Ann Arbor MI, US
Moshe Talpaz - Ann Arbor MI, US
Jeffrey W. Perry - Ypsilanti MI, US
Roderick J. Sorenson - Ann Arbor MI, US
Mary X. O'Riordan - Ann Arbor MI, US
Yafei Jin - Ann Arbor MI, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
International Classification:
A61K 31/541, C12N 5/02, A61K 31/5377, A61K 31/53, A61K 31/50, C07D 413/12, A61K 31/496, A61K 31/505, A61K 31/454, A61K 31/4439, A61K 31/44, A61K 31/433, A61K 31/4245, A61K 31/426, A61K 31/42, A61K 31/4164, A61K 31/415, A61K 31/165, C07D 417/12, C07D 253/065, C07D 253/04, C07D 237/06, C07D 239/02, A61K 31/4965, C07D 401/12, C07D 213/57, C07D 285/06, C07D 285/12, C07D 271/10, C07D 277/30, C07D 261/06, C07D 233/90, C07D 231/10, C07C 255/32, A61P 25/28, A61P 31/04, A61P 31/10, A61P 31/12, A61P 33/00, A61P 35/00, C12N 9/99
US Classification:
5142278, 435184, 435375, 5142372, 514241, 514242, 514247, 5142521, 51425301, 514256, 514326, 514341, 514357, 514361, 514363, 514364, 514365, 514378, 514400, 514406, 514620, 544 60, 544131, 544182, 544215, 544224, 544335, 544336, 544360, 546210, 5462764, 546330, 548127, 548136, 548143, 548204, 548247, 5483361, 5483751, 558392
Abstract:
Disclosed herein are methods of inhibiting a deubiquitinase (DUB), methods of treating pathogenic infections (e.g., viral, bacterial, and/or parasitic), methods of inhibiting cell proliferation, methods of treating a neurodegenerative disease, methods of treating one or more symptoms of a neurodegenerative disease or a genetic disorder, and compounds.