DR. MORTIMER M CIVAN, M.D.
Osteopathic Medicine in Philadelphia, PA
License number
Pennsylvania 130R1522
Category
Osteopathic Medicine
Type
Nephrology
Address
Address
A303 Hamilton Walk Dept. Of Physiology BUILDING 3700, Philadelphia, PA 19104
Phone
(215) 898-8773
(215) 573-5851 (Fax)
(215) 573-5851 (Fax)
Personal information
See more information about MORTIMER M CIVAN at radaris.comName
Address
Phone
233 S 6Th St APT 901, Philadelphia, PA 19106
Philadelphia, PA
1238 Knox Rd, Wynnewood, PA 19096
1238 Knox Rd, Wynnewood, PA 19096
233 6Th St, Philadelphia, PA 19106
Professional information
Professor At University Of Pennsylvania School Of Medicine
Position:
Professor at University of Pennsylvania School of Medicine
Location:
Greater Philadelphia Area
Industry:
Higher Education
Work:
University of Pennsylvania School of Medicine
-
Professor
Effective Delivery Of Cross-Species A3 Adenosine-Receptor Antagonists To Reduce Intraocular Pressure
US Patent:
2009025, Oct 15, 2009
Filed:
Apr 6, 2009
Appl. No.:
12/419062
Inventors:
Mortimer M. Civan - Philadelphia PA, US
Kenneth A. Jacobson - Silver Spring MD, US
Marcel Y. Avila - Bogota, CO
Richard Stone - Havertown PA, US
Kenneth A. Jacobson - Silver Spring MD, US
Marcel Y. Avila - Bogota, CO
Richard Stone - Havertown PA, US
International Classification:
A61K 31/7076, A61P 27/06
US Classification:
514 46, 514 45
Abstract:
Provided are methods for reducing intraocular pressure in an individual having an ocular disorder causing elevated intraocular pressure, such as glaucoma. The method comprises administering to the individual an effective intraocular pressure-reducing amount of a pharmaceutical composition comprising an Asubtype adenosine receptor (AAR) antagonist, including dihydropyridine, pyridine, pyridinium salt or triazoloquinazoline, and derivatives thereof expressly having AAR antagonist activity, including, e.g., the nucleoside-based AAR antagonist, MRS-3820. Further provided is a method for ensuring the delivery of a topically administered therapeutic composition for reducing intraocular pressure, wherein the method expressly requires physically opening a channel through the corneal barrier of the patient's eye by a microneedle or micropipette to permit transport of the topical composition to the anterior chamber of the eye.