Inventors:
Timothy J. McDonnell - Houston TX, US
Stephen G. Swisher - Fresno TX, US
Bingliang Fang - Houston TX, US
Elizabeth M. Bruckheimer - Houston TX, US
Mona G. Sarkiss - Houston TX, US
Lin Ji - SugarLand TX, US
Jack A. Roth - Houston TX, US
Assignee:
Board of Regents, The University of Texas System - Austin TX
International Classification:
A61K048/00, C12N015/861, C12N015/63, C07H021/04
US Classification:
424 932, 424 931, 424 936, 4353201, 435 691, 435455, 435456, 435457, 536 231, 536 232, 536 234, 536 235, 536 241
Abstract:
The present invention generally relates to viral vectors and their use as expression vectors for transforming human cells, both in vitro and in vivo. More particularly, the present invention relates to adenoviral vectors containing propapoptotic genes and their use in cancer therapy.