Inventors:
Mokenge P. Malafa - Tampa FL, US
Said M. Sebti - Tampa FL, US
Assignee:
University of South Florida - Tampa FL
International Classification:
A61K 31/355, A61K 31/513, A61K 31/7052, A61K 31/7105, A61P 35/00
US Classification:
514183, 514274, 514458, 435374
Abstract:
Methods are disclosed for treating neoplastic disorders, such as pancreatic cancer, using tocotrienols; namely, gamma-tocotrienol and delta tocotrienol. The antitumorogenic effects of these compounds are shown both in vitro and in vivo using several human pancreatic cancer cell lines and MIA-PACA2 human pancreatic cancer cells xenografted in nude mice. Also disclosed are methods of testing the efficacy of potential chemotherapeutic agents by measuring their effect on surrogate endpoint biomarkers, such as Ki-67 and p27. Associated compounds are also disclosed.