MLADEN GOLUBIC, M.D., PH.D.
Osteopathic Medicine at Richmond Rd, Cleveland, OH

7931922, Apr 26, 2011

Nov 20, 2009

12/591484

Thomas Newmark - St. Louis MO, US
Mladen Golubic - Cleveland OH, US
Paul Schulick - Brattleboro VT, US

New Chapter Inc. - Brattleboro VT
The Cleveland Clinic Foundation - Cleveland OH

A61K 36/906, A61K 36/53, A61K 36/82, A61K 36/00

424756, 424745, 424729, 424725, 424777

The inventive subject matter relates to methods for treating glioblastoma, comprising administration of a composition comprising therapeutically effective amounts of supercritical extracts of rosemary, turmeric, oregano and ginger; and therapeutically effective amounts of hydroalcoholic extracts of holy basil, ginger, turmeric, , rosemary, green tea, huzhang, Chinese goldthread, and barberry. The inventive subject matter further relates to methods for modulating gene expression of genes selected from the group consisting of interleukin-1α, interleukin-1β, heme oxygenase 1, aldo-keto reductase family 1, member C2, colony stimulating factor 3, leukemia inhibitory factor, heat shock 70 kDa protein, and combinations thereof, by administration of an effective amount of said compositions.

2006007, Apr 13, 2006

Sep 14, 2005

11/225895

Thomas Newmark - St. Louis MO, US
Mladen Golubic - Cleveland OH, US
Paul Schulick - Brattleboro VT, US

A61K 36/9068, A61K 36/9066, A61K 36/82, A61K 36/53, A61K 36/539

424729000, 424745000, 424756000, 424741000, 424777000

The inventive subject matter relates to methods for treating glioblastoma, comprising administration of a composition comprising therapeutically effective amounts of supercritical extracts of rosemary, turmeric, oregano and ginger; and therapeutically effective amounts of hydroalcoholic extracts of holy basil, ginger, turmeric, , rosemary, green tea, huzhang, Chinese goldthread, and barberry. The inventive subject matter further relates to methods for modulating gene expression of genes selected from the group consisting of interleukin-1α, interleukin-1β, heme oxygenase 1, aldo-keto reductase family 1, member C2, colony stimulating factor 3, leukemia inhibitory factor, heat shock 70 kDa protein, and combinations thereof, by administration of an effective amount of said compositions.

2011020, Aug 18, 2011

Mar 24, 2011

13/071001

Thomas NEWMARK - St. Louis MO, US
Mladen GOLUBIC - Cleveland OH, US
Paul SCHULICK - Brattleboro VT, US

NEW CHAPTER INC. - Brattleboro VT
THE CLEVELAND CLINIC FOUNDATION - Cleveland OH

A61K 36/82, A61P 35/00

424729

The inventive subject matter relates to methods for treating glioblastoma, comprising administration of a composition comprising therapeutically effective amounts of supercritical extracts of rosemary, turmeric, oregano and ginger; and therapeutically effective amounts of hydroalcoholic extracts of holy basil, ginger, turmeric, , rosemary, green tea, huzhang, Chinese goldthread, and barberry. The inventive subject matter further relates to methods for modulating gene expression of genes selected from the group consisting of interleukin-1α, interleukin-1β, heme oxygenase 1, aldo-keto reductase family 1, member C2, colony stimulating factor 3, leukemia inhibitory factor, heat shock 70 kDa protein, and combinations thereof, by administration of an effective amount of said compositions.