Inventors:
Richard A. Bond - San Francisco TX, US
Mitchell Glass - Wilmington DE, US
International Classification:
A61K 31/138, A61K 45/06
US Classification:
424 48, 514651, 514411, 514171, 514367, 514250, 514398
Abstract:
The chronic use of p-adrenergic inverse agonists such as nadolol, carvedilol, and ICI-118,551 provides an improved method for the treatment of mucus hypersecretion in subjects with such mucus hypersecretion. One aspect of a method according to the present invention is a method of preventing or controlling mucus hypersecretion in the respiratory tract comprising administering a therapeutically effective quantity of a p-adrenergic inverse agonist to a subject with mucus hypersecretion or at risk of mucus hypersecretion. The invention further encompasses pharmaceutical compositions comprising the p-adrenergic inverse agonist and the additional compound.