Inventors:
Aleksandr Nikolayev - Maple Shade NJ
Fakrul Sayeed - Voorhees NJ
Rupa Iyer - Marlton NJ
Mitchell Garber - Cherry Hill NJ
Robert C. Butterhof - Southampton NJ
Todd M. Hoyer - Trenton NJ
Marvin Samson - Cherry Hill NJ
Assignee:
Schein Pharmacetical, Inc. - Florham Park NJ
International Classification:
C07C 5900, C07C 5143, A01N 3706
Abstract:
Polyethoxylated castor oil with a low cation content are claimed, along with particular methods for achieving such low cation content polyethoxylated castor oil. One method of production of such a low cationic content polyethoxylated castor oil according to the invention is to pre-treat the polyethoxylated castor oil with a strong cationic exchange resin to remove a substantial portion of the cations present in an untreated polyethoxylated castor oil. The low cationic content polyethoxylated castor oil of the invention can then be utilized to prepare formulations of various agents which are found to be sensitive to the previously commercially available polyethoxylated castor oil (CREMOPHOR EL. RTM. ).