Inventors:
Ralph Buttyan - New York NY, US
Mitchell Benson - New York NY, US
Min-Wei Chen - Flushing NY, US
Francis Vacherot - Creteil, FR
Luis Carlos Soares Queires - Salvador, BR
Stephane Terry - Creteil, FR
Alexandre De La Taille - Paris, FR
Sixtina Gil Diez De Medina - Paris, FR
Assignee:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY
INSERM - Paris
International Classification:
A61K 51/00, A01K 67/00, A61K 31/7052, C07H 21/00, C12N 1/00, C12Q 1/68, G01N 33/53, C12N 5/00, C07K 16/00, A61K 38/00, A61K 39/395
US Classification:
424001490, 424001110, 424001690, 424001730, 424130100, 424009100, 435243000, 435325000, 435410000, 435006000, 435007100, 514001000, 514002000, 514044000, 530387900, 530388100, 536023100, 800013000, 800014000, 800015000, 800017000, 800018000, 800003000
Abstract:
The invention is directed to compounds and methods for treating or preventing hormone-resistant prostate cancer using siRNA specific for protocadherin-PC, or other inhibitors of protocadherin-PC expression or activity, including antisense oligonucleotides and antibodies. The invention also provides for the use of protocadherin-PC as an in vivo prostate cancer biomarker, and includes a kit for detecting prostate cancer in biological samples. Also covered by the invention is a transgenic non-human mammal engineered to overexpress protocadherin-PC specifically in the prostate.