Inventors:
Daniel J. Finley - Jamaica Plain MA, US
Randall W. King - Brookline MA, US
Byung-Hoon Lee - Cambridge MA, US
Min J. Lee - Jamaica Plain MA, US
Timothy C. Gahman - Encinitas CA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
A61K 31/454, C12N 5/071, A61P 43/00, C40B 30/08, C12N 9/50, C07D 401/06, C12N 9/99, C12N 9/96
US Classification:
514326, 435184, 435375, 435188, 506 11, 435219, 546208
Abstract:
Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp 14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.