MILO E WEBSTER
Engineering in Braintree, MA

4848722, Jul 18, 1989

Feb 11, 1988

7/155038

Milo E. Webster - Braintree MA

Integrated Fluidics, Inc. - Plainville CT

F16K 712

251 611

A valve is disclosed comprising a first body portion (2) having a first surface (16), a second body portion (4) having a second surface (51) facing the first surface, a flexible sheet (8) positioned between the first and second surfaces, a void (4) in the first body portion created and defined by a concave surface (46) formed in the first surface and one side (18) of the flexible sheet. There are at least two fluid passageways (20) (22) in the first body portion communicating with the void at spaced locations, at least one of the fluid passageways being a channel formed in the first surface and terminating at the void. A source of pressure and vacuum (50) (54) is provided for flexing the sheet against and away from the first body portion in order that when the flexible sheet is flexed against the first body portion, the passageways are sealed from each other, and when the flexible sheet is flexed away from the first body portion the fluid passageways are placed in communication with each other by way of the void.

4858883, Aug 22, 1989

Dec 8, 1988

7/281544

Milo E. Webster - Braintree MA

Integrated Fluidics, Inc. - Plainville CT

F16K 712

251 611

A valve is disclosed comprising a first body portion (2) having a first surface (16), a second body portion (4) having a second surface (51) facing the first surface, a flexible sheet (8) positioned between the first and second surfaces, a void (4) in the first body portion created and defined by a concave surface (46) formed in the first surface and one side (18) of the flexible sheet. There are at least two fluid passageways (20) (22) in the first body portion communicating with the void at spaced locations, at least one of the fluid passageways being a channel formed in the first surface and terminating at the void. A source of pressure and vacuum (50) (54) is provided for flexing the sheet against and away from the first body portion in order that when the flexible sheet is flexed against the first body portion, the passageways are sealed from each other, and when the flexible sheet is flexed away from the first body portion the fluid passageways are placed in communication with each other by way of the void.

4852851, Aug 1, 1989

Dec 11, 1987

7/131751

Milo E. Webster - Braintree MA

Integrated Fluidics, Inc. - Plainville CT

F16K 712

251 611

A valve is disclosed comprising a first body portion (2) having a first surface (16), a second body portion (4) having a second surface (51) facing the first surface, a flexible sheet (8) positioned between the first and second surfaces, a void (4) in the first body portion created and defined by a concave surface (46) formed in the first surface and one side (18) of the flexible sheet. There are at least two fluid passageways (20) (22) in the first body portion communicating with the void at spaced locations, at least one of the fluid passageways being a channel formed in the first surface and terminating at the void. A source of pressure and vacuum (50) (54) is provided for flexing the sheet against and away from the first body portion in order that when the flexible sheet is flexed against the first body portion, the passageways are sealed from each other, and when the flexible sheet is flexed away from the first body portion the fluid passageways are placed in communication with each other by way of the void.

5041181, Aug 20, 1991

Aug 23, 1990

7/571937

Tom S. Brackett - New Britain CT
Milo E. Webster - Braintree MA

Integrated Fluidics Company - Plainville CT

B32B 3112

156 84

A method of producing a fluidic module from two or more pieces (B. sub. 1 B. sub. 2) of plastic material having an intermolecular bonded interface, comprises forming an interface surface (2) on each piece, forming at least one fluidic passageway (4) in at least one of the interface surfaces, assembling the pieces with the interface surfaces in contact with each other and confining them against expansion. Heat is applied to the assembled pieces to induce their expansion against total or limited confinement to cause transmigration of molecules from one interface surface to the other to bond the pieces together.

4601881, Jul 22, 1986

Nov 1, 1984

6/667299

Milo E. Webster - Braintree MA

Allied Corporation - Morristown NJ

G01N 2100, G01N 3100, G01N 3300

422 67

A liquid handling system useful in apparatus for analyzing biological liquid specimens or the like includes a plurality of sample metering chambers, a distribution manifold connected between a sample inlet port and the sample metering chambers, and a corresponding plurality of auxiliary liquid metering chambers connected to corresponding auxiliary liquid reservoirs. Liquids are flowed from the sample inlet port through the distribution manifold to the sample metering chambers and from auxiliary liquid reservoirs to the auxiliary liquid metering chambers under the influence of reduced pressures which are selectively connected to the flow network through an integrated valve array and reduced pressure manifolds.

4282182, Aug 4, 1981

Apr 20, 1980

6/142463

Milo E. Webster - Braintree MA

Instrumentation Laboratory Inc. - Lexington MA

G01N 110, G01N 124

422 68

Apparatus for analyzing the contents of a sealed package includes a package alignment assembly, and a probe assembly that has a puncturing tip. The package alignment assembly includes a positioning support surface in alignment with the puncturing tip and supplemental resiliently supported structure spaced from the support surface for aligning the package to be analyzed with the probe assembly. A flow path extends from the puncturing tip to an analysis unit for withdrawing and analyzing a sample of the contents of the package.

4304257, Dec 8, 1981

Jul 1, 1980

6/165103

Milo E. Webster - Braintree MA

Instrumentation Laboratory Inc. - Lexington MA

F16K 716

137559

A valve that is particularly useful in biological fluid handling systems includes a body member that has a firm and stable support surface and a flexible sheet member that has a surface for conforming and mating engagement with the surface of the valve body member. A land portion in the surface of one of the valve members separates two fluid flow channels in that member. An actuator is arranged to flex the sheet member between a first position in which the surface of the sheet member is in mating and sealing engagement with the surface of the body member to sealing block flow between the two channels, and a second position in which the sheet surface is spaced from the first position to allow fluid flow across the land surface between the two flow channels.

4999069, Mar 12, 1991

Jun 2, 1989

7/360267

Tom S. Brackett - New Britain CT
Milo E. Webster - Braintree MA

Integrated Fluidics, Inc. - Plainville CT

B32B 3112

156 84

A method of producing a fluidic module from two or more pieces (B. sub. 1 B. sub. 2) of plastic material having an intermolecular bonded interface, comprises forming an interface surface (2) on each piece, forming at least one fluidic passageway (4) in at least one of the interface surfaces, assembling the pieces with the interface surfaces in contact with each other and confining them against expansion. Heat is applied to the assembled pieces to induce their expansion against total or limited confinement to cause transmigration of molecules from one interface surface to the other to bond the pieces together.

4859422, Aug 22, 1989

Jul 17, 1987

7/075052

Humayun Qureshi - Wayland MA
Stanley M. Liffmann - Andover MA
Milo E. Webster - Braintree MA
Theodore S. Geiselman - Groveland MA

Fisher Scientific Company - Pittsburgh PA

G01N 3500

422 81

An analysis system includes sample insertion module structure with structure defining a reduced pressure reservoir, structure defining a sample region, and structure defining a reagent circuit that includes metering chamber structure in series with the reagent circuit. First transfer valve structure is arranged to couple the sample region to the reagent circuit on one side of the metering chamber structure, and second transfer valve structure is arranged to couple the reagent circuit to the reduced pressure reservoir structure on the side of the metering chamber structure remote from the first transfer valve structure for inserting an intact metered quantity of sample liquid into a reagent stream.

4268479, May 19, 1981

Jan 10, 1980

6/111015

Milo E. Webster - Braintree MA

Instrumentation Laboratory Inc. - Lexington MA

G01N 110

422 68

A portable fluid analyzer has a sampling section with flow passage structure for sealing engagement with a discharge port of a zwickel fitting or the like and retainer structure for engagement with the fitting. The retainer structure is urged by a spring towards a retaining position and is movable, by a manual operator towards a released position. When the retainer structure is engaged with the fitting and the manual operator is released, the sealing member is urged by the spring into engagement with the fitting's discharge port. The analyzer also includes an analysis chamber connected to the discharge end of the flow passage structure and monitoring means for providing an output as a function of a constituent of the fluid in the analysis chamber.