Inventors:
John R. Cashman - San Diego CA, US
Milan Fiala - Los Angeles CA, US
International Classification:
A61K 35/14, A61K 31/12, C12Q 1/02, G01N 33/00, C07C 69/76, C07C 49/00, C12Q 1/48, A61P 25/28
US Classification:
424529, 514679, 435 29, 436 94, 560 55, 568308, 435 15
Abstract:
Disclosed are methods for identifying individuals suffering from a CNS disorder (including Alzheimer's Disease, behavioral disorders, and the like) that could be treated with a CNS drug with greater therapeutic efficacy and lower side effects and the compounds useful for such treatment. Also disclosed are methods for predicting the efficacy of a drug candidate for the treatment of a CNS disorder. The technology is also applicable to drug discovery for use in animal models of neurodegenerative diseases.