Inventors:
Susan Waltz - Loveland OH, US
Mike Leonis - Norwood OH, US
Sandra Degen - Cincinnati OH, US
Assignee:
Children's Hospital Medical Center
International Classification:
A61K048/00, A61K039/395, A61K038/43
US Classification:
514/044000, 424/146100, 424/094100
Abstract:
The present invention relates to the prevention and treatment of injury and diseases to the liver, biliary tract, bile ducts, gall bladder and related hepatobiliary system. Specifically, the present invention relates to methods for decreasing the action of the RON receptor tyrosine kinase in liver physiology. More specifically, the present invention relates to the use of analogs and antagonists and antibodies for inhibiting the action of the RON receptor tyrosine kinase for the prevention and treatment of liver injury or damage in acute and chronic clinical conditions.