Inventors:
Mika K. Derynck - San Mateo CA, US
Jennifer O'Hara Lauchle - Larkspur CA, US
International Classification:
A61K 31/5377, A61K 31/7068, A61K 33/24, A61P 35/00, A61K 39/395
US Classification:
4241331, 5142342, 424649, 514 49
Abstract:
Methods are provided for treating mesothelioma patients with a dual PI3K/mTOR inhibitor, GDC-0980: (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin--yl)-2-hydroxypropan--one, and having the structure: