Inventors:
Shohei Koide - Chicago IL, US
Stephen Dewhurst - Rochester NY, US
Akiko Koide - Chicago IL, US
Julie Richards - Rochester NY, US
Michelle Miller - Rochester NY, US
Assignee:
University of Rochester - Rochester NY
International Classification:
G01N 33/53, A61K 39/00, A61K 39/385, C07K 14/00, C07K 1/00
US Classification:
435 71, 435 72, 435 78, 4241921, 4241931, 530350, 530400
Abstract:
The present invention relates to a polypeptide monobody which includes a modified acid sequence and renders the polypeptide monobody able to bind selectively to ανβ3 integrin. Fusion proteins and conjugates which include the polypeptide monobody, as well as compositions containing the polypeptide monobody, fusion proteins, or conjugates are also disclosed. Uses thereof include: treating or preventing an ανβ3 integrin-mediated disease or disorder, inhibiting ανβ3 integrin activity, treating a cancerous or precancerous condition, imaging tissues using positron emission tomography or magnetic resonance imaging, assessing the metastatic characteristics of a tumor, and delivering DNA to a cell.