Inventors:
Sylvaine Cases - San Francisco CA, US
Sandra K. Erickson - San Francisco CA, US
Sabine Novak - Munich, DE
Michel Accad - San Francisco CA, US
Assignee:
The Regents of the Universtiy of California - Oakland CA
The United States of America as represented by the Department of Veteran Affairs - Washington DC
International Classification:
A01N043/04, A61K031/70, A61K038/00, C12N009/00, C12N005/00
US Classification:
514 44, 514 12, 536 231, 536410, 536 232, 536348, 536 235, 435 32, 435377, 4352523, 435193
Abstract:
Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with ACAT-2 activity, e. g. , in the treatment of gall stones.