DR. MICHEL E. MAWAD, M.D.
Radiology at South Fwy, Houston, TX

6428462, Aug 6, 2002

Mar 15, 2000

09/526322

Michel E. Mawad - Houston TX 77005

A61N 500

600 3

A radiotherapy device comprises a radioactive wire adapted to deliver an intended dosage of radiation to a lesion or other selected body tissues. The radioactive wire comprises an inner core about which is disposed an outer buffer layer of platinum or other suitable metal of high atomic number. The buffer layer preferably comprises a thin, continuous wire wrapped about the inner core. The radiotherapy device may be made into a variety of shapes, such as a straight wire, a helical coil, or other more complex shape, and it may be provided with an elastic memory. The device may be adapted for attachment to a delivery wire for controlled placement, as through a delivery catheter or microcatheter, at the treatment site. When accurate positioning of the device is not necessary, it can simply be injected through the delivery catheter or microcatheter, and in that event a delivery wire is not needed. The device may be provided with mechanically or electrically releasable means for attachment to the delivery wire during delivery, and for releasing the device at the treatment site.

5498227, Mar 12, 1996

Sep 15, 1993

8/122199

Michel E. Mawad - Houston TX

A61N 500

600 3

A radiotherapy device comprises a radioactive wire adapted to deliver an intended dosage of radiation to a lesion or other selected body tissues. The radioactive wire comprises an inner core about which is disposed an outer buffer layer of platinum or other suitable metal of high atomic number. The buffer layer preferably comprises a thin, continuous wire wrapped about the inner core. The radiotherapy device may be made into a variety of shapes, such as a straight wire, a helical coil, or other more complex shape, and it may be provided with an elastic memory. The device may be adapted for attachment to a delivery wire for controlled placement, as through a delivery catheter or microcatheter, at the treatment site. When accurate positioning of the device is not necessary, it can simply be injected through the delivery catheter or microcatheter, and in that event a delivery wire is not needed. The device may be provided with mechanically or electrically releasable means for attachment to the delivery wire during delivery, and for releasing the device at the treatment site.

6056686, May 2, 2000

Mar 11, 1996

8/615566

Michel E. Mawad - Houston TX

A61N 500

600 3

A radiotherapy device comprises a radioactive wire adapted to deliver an intended dosage of radiation to a lesion or other selected body tissues. The radioactive wire comprises an inner core about which is disposed an outer buffer layer of platinum or other suitable metal of high atomic number. The buffer layer preferably comprises a thin, continuous wire wrapped about the inner core. The radiotherapy device may be made into a variety of shapes, such as a straight wire, a helical coil, or other more complex shape, and it may be provided with an elastic memory. The device may be adapted for attachment to a delivery wire for controlled placement, as through a delivery catheter or microcatheter, at the treatment site. When accurate positioning of the device is not necessary, it can simply be injected through the delivery catheter or microcatheter, and in that event a delivery wire is not needed. The device may be provided with mechanically or electrically releasable means for attachment to the delivery wire during delivery, and for releasing the device at the treatment site.

2012024, Sep 27, 2012

May 6, 2010

13/319012

Shi Ke - Houston TX, US
Michel Mawad - Houston TX, US
Wei Wang - Houston TX, US

BAYLOR COLLEGE OF MEDICINE - Houston TX

C07D 403/08, A61K 49/04, A61K 49/00

424 944, 548455, 424 96, 424 91

The present invention provides nonradioactive NIR optical imaging agents based up on the structure of retinoid acid derivatives. The nonradioactive NIR optical imaging agent has been evaluated at the cellular level by confocal microscopy, and in vivo in a whole animal using a various xenograft models. The specific uptake of this agent in human cancer cells and multiple xenograft models demonstrate that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for early stage cancer studies and diagnoses. Also, the present invention provides that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for visualization of drug redistribution within the body which is useful in determining the optimal biological dose. Ultimately, the visualization data can be used as an analytical tool to reduce any systemic toxicity.

2006018, Aug 17, 2006

Feb 15, 2005

11/058131

Christof Karmonik - Houston TX, US
Michel Mawad - Houston TX, US

Baylor College of Medicine - Houston TX

A61B 5/103

600587000

A method of creating a surface model of an intracranial aneurysm in an artery having a lumen, the aneurysm having a neck and a dome and the virtual reconstruction of the parent artery across the lateral extension of the aneurysm neck. The method includes the steps of: determining a center and radius of the artery over the lateral extension of the aneurysm; determining the boundary points that mark the boundary between the aneurysm neck and the artery; determining the angle of the aneurysm neck with respect to the artery, for various cross sections of the neck; determining the length of the neck; determining the height of the dome; estimating the area of the neck; and creating the surface model of the intracranial aneurysm in the artery, using the results from the previous steps.

2013022, Aug 29, 2013

Apr 1, 2011

13/638060

Wei Wang - Houston TX, US
Jason Shohet - Houston TX, US
Michel Mawad - Houston TX, US
Shi Ke - Missouri City TX, US

Baylor College of Medicine - Houston TX

C07D 209/26

424 91, 548455

Multi-modal tumor imaging of neuroblastoma is essential for tumor staging, response evaluation and detection of relapsed diseased. The present invention provides a norepinephine analogue with a near-infrared (near-IR) dye, W765-BG, that efficiently and stably detects neuroblastoma in vivo using near-IR optical imaging. Confocal microscopy and optical imaging of neuroblastoma xenografts shows cell specific uptake and reveals exceptional tumor retention with a high tumor-to-tissue ratio up to 7 days after injection of W765-BG.

2005016, Jul 28, 2005

Jan 12, 2004

10/755249

Michel Mawad - Houston TX, US

A61M031/00

604500000, 606191000, 604104000

A catheter for providing an embolic material at a desired location comprises a flexible tubular member having a proximal end and a distal end, the tubular member including at least one ring of expansible material affixed to its outer surface less than 25 mm from the distal end. The ring preferably comprises a material that expands in volume when in contact with a liquid, such as a hydrogel or hydrogel foam, or in response to an application of heat. The ring is fully expanded after between 10 and 30 minutes of contact with a liquid. The catheter may also include further including a plurality of radioopaque markers spaced along the tubular member at predetermined intervals.

2014000, Jan 2, 2014

Jan 13, 2012

13/979173

Michel Mawad - Houston TX, US

Baylor College of Medicine - Houston TX

A61B 5/00

382130

A method of angiographic evaluation of a flow diverter in a region of interest having abnormal flow in a vessel of interest, the method using digital division angiogram images at a first segment at or near a proximal end of the region of interest and at a second segment at or near a distal end of the region of interest, and observing differences in flow seen at said first and second segments.