Michael X. Xia
Electrician in Wilmington, DE
License number
Delaware TH-0002386
Issued Date
Mar 16, 2006
Expiration Date
Mar 16, 2007
Category
Electrical Examiners
Type
Homeowner's Permit
Address
Address
2
Wilmington, DE 19810
Professional information
Processes For Preparing Jak Inhibitors And Related Intermediate Compounds
US Patent:
8410265, Apr 2, 2013
Filed:
Jan 14, 2010
Appl. No.:
12/687623
Inventors:
Jiacheng Zhou - Newark DE, US
Pingli Liu - Newark DE, US
Qiyan Lin - Newark DE, US
Brian W. Metcalf - Moraga CA, US
David Meloni - Bear DE, US
Yongchun Pan - Newark DE, US
Michael Xia - Wilmington DE, US
Mei Li - Newark DE, US
Tai-Yuen Yue - Hockessin DE, US
James D. Rodgers - Landenberg PA, US
Haisheng Wang - Hockessin DE, US
Pingli Liu - Newark DE, US
Qiyan Lin - Newark DE, US
Brian W. Metcalf - Moraga CA, US
David Meloni - Bear DE, US
Yongchun Pan - Newark DE, US
Michael Xia - Wilmington DE, US
Mei Li - Newark DE, US
Tai-Yuen Yue - Hockessin DE, US
James D. Rodgers - Landenberg PA, US
Haisheng Wang - Hockessin DE, US
Assignee:
Incyte Corporation - Wilmington DE
International Classification:
C07D 487/00
US Classification:
544280
Abstract:
The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
Azetidine And Cyclobutane Derivatives As Jak Inhibitors
US Patent:
2013022, Aug 29, 2013
Filed:
Mar 29, 2013
Appl. No.:
13/853475
Inventors:
Stacey SHEPARD - Voorhees NJ, US
Yun-Long LI - Chadds Ford PA, US
Jiacheng ZHOU - Newark NJ, US
Pingli LIU - Newark NJ, US
David MELONI - Bear DE, US
Michael XIA - Wilmington DE, US
Yun-Long LI - Chadds Ford PA, US
Jiacheng ZHOU - Newark NJ, US
Pingli LIU - Newark NJ, US
David MELONI - Bear DE, US
Michael XIA - Wilmington DE, US
Assignee:
Incyte Corporation - Wilmington DE
International Classification:
C07D 487/04
US Classification:
51421021, 544280, 5142651
Abstract:
The present invention relates to azetidine and cyclobutane derivatives, as well as their compositions, methods of use, and processes for preparation, which are JAK inhibitors useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
Azetidine And Cyclobutane Derivatives As Jak Inhibitors
US Patent:
2012007, Mar 29, 2012
Filed:
Dec 9, 2011
Appl. No.:
13/315750
Inventors:
James D. RODGERS - OveLandenberg PA, US
Stacey SHEPARD - Voorhees NJ, US
Yun-Long LI - Chadds Ford PA, US
Jiacheng ZHOU - Newark NJ, US
Pingli LIU - Newark NJ, US
David MELONI - Bear DE, US
Michael XIA - Wilmington DE, US
Stacey SHEPARD - Voorhees NJ, US
Yun-Long LI - Chadds Ford PA, US
Jiacheng ZHOU - Newark NJ, US
Pingli LIU - Newark NJ, US
David MELONI - Bear DE, US
Michael XIA - Wilmington DE, US
International Classification:
A61K 31/519, A61P 25/00, C07D 487/04, A61P 41/00, A61P 19/02, A61P 29/00, A61P 1/00, A61P 17/06, A61P 37/08, A61P 35/00, A61P 35/02, A61P 17/00, A61P 3/10
US Classification:
51421018, 51421021, 5142651, 544280
Abstract:
The present invention relates to azetidine and cyclobutane derivatives, as well as their compositions, methods of use, and processes for preparation, which are JAK inhibitors useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
Azetidine And Cyclobutane Derivatives As Jak Inhibitors
US Patent:
2009023, Sep 17, 2009
Filed:
Mar 10, 2009
Appl. No.:
12/401348
Inventors:
James D. Rodgers - Landenberg PA, US
Stacey Shepard - Voorhees NJ, US
Yun-Long Li - Chadds Ford PA, US
Jiacheng Zhou - Newark DE, US
Pingli Liu - Newark DE, US
David Meloni - Bear DE, US
Michael Xia - Wilmington DE, US
Stacey Shepard - Voorhees NJ, US
Yun-Long Li - Chadds Ford PA, US
Jiacheng Zhou - Newark DE, US
Pingli Liu - Newark DE, US
David Meloni - Bear DE, US
Michael Xia - Wilmington DE, US
Assignee:
INCYTE CORPORATION - Wilmington DE
International Classification:
A61K 31/519, C07D 487/04, A61P 35/00
US Classification:
51421021, 544280, 5142651
Abstract:
The present invention relates to azetidine and cyclobutane derivatives, as well as their compositions, methods of use, and processes for preparation, which are JAK inhibitors useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
Purinone Derivatives As Hm74A Agonists
US Patent:
8039478, Oct 18, 2011
Filed:
Nov 3, 2008
Appl. No.:
12/263990
Inventors:
Changsheng Zheng - Wilmington DE, US
Ganfeng Cao - Bear DE, US
Michael Xia - Wilmington DE, US
Anlai Wang - Wilmington DE, US
Hai Fen Ye - Newark DE, US
Brian Metcalf - Moraga CA, US
Ganfeng Cao - Bear DE, US
Michael Xia - Wilmington DE, US
Anlai Wang - Wilmington DE, US
Hai Fen Ye - Newark DE, US
Brian Metcalf - Moraga CA, US
Assignee:
Incyte Corporation - Wilmington DE
International Classification:
A01N 43/54, A61K 31/505, C07D 239/00, C07D 487/00
US Classification:
514267, 544251
Abstract:
The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
Purinone Derivatives As Hm74A Agonists
US Patent:
7511050, Mar 31, 2009
Filed:
Jun 22, 2007
Appl. No.:
11/766981
Inventors:
Changsheng Zheng - Wilmington DE, US
Ganfeng Cao - Bear DE, US
Michael Xia - Wilmington DE, US
Anlai Wang - Wilmington DE, US
Hai Fen Ye - Newark DE, US
Brian Metcalf - Moraga CA, US
Ganfeng Cao - Bear DE, US
Michael Xia - Wilmington DE, US
Anlai Wang - Wilmington DE, US
Hai Fen Ye - Newark DE, US
Brian Metcalf - Moraga CA, US
Assignee:
Incyte Corporation - Wilmington DE
International Classification:
A01N 43/54, A61K 31/505, C07D 239/00, C07D 471/00, C07D 487/00, C07D 491/00
US Classification:
514267, 544251
Abstract:
The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
Purinone Derivatives As Hm74A Agonists
US Patent:
2012003, Feb 9, 2012
Filed:
Oct 17, 2011
Appl. No.:
13/275214
Inventors:
Changsheng Zheng - Wilmington DE, US
Ganfeng Cao - Wilmington DE, US
Michael Xia - Wilmington DE, US
Anlai Wang - Wilmington DE, US
Hai Fen Ye - Newark DE, US
Brian Metcalf - Moraga CA, US
Ganfeng Cao - Wilmington DE, US
Michael Xia - Wilmington DE, US
Anlai Wang - Wilmington DE, US
Hai Fen Ye - Newark DE, US
Brian Metcalf - Moraga CA, US
Assignee:
INCYTE CORPORATION - Wilmington DE
International Classification:
A61K 31/5377, C07D 413/14, A61P 9/12, A61P 3/10, A61P 9/10, A61P 3/06, C07D 471/14, A61K 31/519
US Classification:
5142332, 544346, 544115, 514267
Abstract:
The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
3-Aminocyclopentanecarboxamides As Modulators Of Chemokine Receptors
US Patent:
8470827, Jun 25, 2013
Filed:
Sep 25, 2008
Appl. No.:
12/238121
Inventors:
Changsheng Zheng - Cary NC, US
Hao Feng - Aston PA, US
Michael Xia - Wilmington DE, US
Joseph Glenn - Mount Royal NJ, US
Ganfeng Cao - Newark DE, US
Brian W. Metcalf - Moraga CA, US
Hao Feng - Aston PA, US
Michael Xia - Wilmington DE, US
Joseph Glenn - Mount Royal NJ, US
Ganfeng Cao - Newark DE, US
Brian W. Metcalf - Moraga CA, US
Assignee:
Incyte Corporation - Wilmington DE
International Classification:
A61K 31/497, A61K 31/445, C07D 403/12, C07D 241/10, C07D 401/12, C07D 211/80
US Classification:
51425301, 51425411, 514318, 544295, 544358, 544360, 546194, 546195
Abstract:
The present invention is directed to compounds of Formula I:.