MICHAEL WILLIAM KING
Pilots at Dobbs Gln St, Terre Haute, IN
License number
Indiana A4736456
Issued Date
Nov 2016
Expiration Date
Nov 2018
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
646 S Dobbs Glen St, Terre Haute, IN 47803
Personal information
See more information about MICHAEL WILLIAM KING at radaris.comName
Address
Phone
4929 S 700 W, Mentone, IN 46539
Professional information
Tumor Necrosis Factor (Tnf) Inhibitor And Method For Obtaining The Same
US Patent:
6143866, Nov 7, 2000
Filed:
Jan 19, 1995
Appl. No.:
8/375242
Inventors:
Michael T. Brewer - Boulder CO
Karin K. Hale - Boulder CO
Michael W. King - Terre Haute IN
Tadahiko Kohno - Louisville CO
Charles Squires - Boulder CO
Robert C. Thompson - Boulder CO
Rebecca W. Vanderslice - Boulder CO
James Vannice - Boulder CO
Karin K. Hale - Boulder CO
Michael W. King - Terre Haute IN
Tadahiko Kohno - Louisville CO
Charles Squires - Boulder CO
Robert C. Thompson - Boulder CO
Rebecca W. Vanderslice - Boulder CO
James Vannice - Boulder CO
Assignee:
Amgen, Inc. - Thousand Oaks CA
International Classification:
C07K 14705, C12N 100
US Classification:
530350
Abstract:
At least two substantially purified tumor necrosis factor (TNF) inhibitors are disclosed which are glycoproteins that are active against TNF. The isolation of 3O kDa and 40 KDa TNF inhibitor from urine is disclosed. The deglycosylated form of the 3O kDa TNF inhibitor and 40 kDa TNF inhibitor are described as being active against TNF. The 40 kDa TNF inhibitor is active against both TNF alpha a TNF beta. The amino acid sequence of the 30 kDa TNF inhibitor and the 40 kDa TNF inhibitor are disclosed. Methods for isolating the TNF inhibitors from human U937 cell medium and producing the proteins by recombinant-DNA methods are also described.