DR. MICHAEL WILLIAM CLIMO, M.D.
Osteopathic Medicine at Broad Rock Blvd, Richmond, VA

6569830, May 27, 2003

Mar 5, 1999

09/263776

Michael Climo - Richmond VA
Ellen Murphy - Bronx NY
Gordon Archer - Richmond VA

Ambi, Inc. - Purchase NY

A61K 3800

514 2, 424 9463, 435183, 435220

Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective against staphylococci due to antibiotic activity mediated by cell-wall activity is effective against staphylococcal infection, even staphylococci that may be resistant to one or other of lysostaphin or the cell-wall active antibiotic. Co-administration simultaneously suppresses the generation of antibiotic-resistant mutant strains. Effective cell-wall active antibiotics include -lactams and glycopeptides.

8198231, Jun 12, 2012

Jun 2, 2006

11/445289

Michael Climo - Richmond VA, US
Ellen Murphy - Bronx NY, US
Gordon Archer - Richmond VA, US

Nutrition 21, Inc. - Purchase NY

A61K 38/00, A61K 38/16, A61K 38/48

514 11, 424 9463, 435183, 435220

Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of cell walls such as lysostaphin and an antibiotic effective against due to antibiotic activity mediated by cell-wall activity is effective against staphylococcal infection, even that may be resistant to one or other of lysostaphin or the cell-wall active antibiotic. Co-administration simultaneously suppresses the generation of antibiotic-resistant mutant strains. Effective cell-wall active antibiotics include β-lactams and glycopeptides.

7078377, Jul 18, 2006

Sep 19, 2000

09/665077

Michael Climo - Richmond VA, US
Ellen Murphy - Bronx NY, US
Gordon Archer - Richmond VA, US

Nutrition 21, Inc. - Purchase NY

A61K 38/00, A61K 38/16, A61K 38/48

514 2, 514 37, 424 9463, 435183, 435220

Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective against staphylococci due to antibiotic activity mediated by cell-wall activity is effective against staphylococcal infection, even staphylococci that may be resistant to one or other of lysostaphin or the cell-wall active antibiotic. Co-administration simultaneously suppresses the generation of antibiotic-resistant mutant strains. Effective cell-wall active antibiotics include β-lactams and glycopeptides.

7122514, Oct 17, 2006

Apr 16, 2003

10/414566

Michael Climo - Richmond VA, US
Ellen Murphy - Bronx NY, US
Gordon Archer - Richmond VA, US

Nutrition 21, Inc. - Purchase NY

A61K 38/00, A61K 38/16, A61K 38/48

514 2, 424 9463, 435183, 435220

Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of cell walls such as lysostaphin and an antibiotic effective against due to antibiotic activity mediated by cell-wall activity is effective against staphylococcal infection, even that may be resistant to one or other of lysostaphin or the cell-wall active antibiotic. Co-administration simultaneously suppresses the generation of antibiotic-resistant mutant strains. Effective cell-wall active antibiotics include β-lactams and glycopeptides.

2002000, Jan 17, 2002

Jul 21, 1998

09/120030

BETH P GOLDSTEIN - TARRYTOWN NY, US
MICHAEL W CLIMO - RICHMOND VA, US
RICHARD P NOVICK - NEW YORK NY, US
GORDON L ARCHER - RICHMOND VA, US

A61K039/40, G01N033/569

424/165100, 435/007330

Lysostaphin is demonstrated to be a powerful anti-staphylococcal agent suitable for parenteral administration to mammals including humans. Low dosages, on the order of 0.5 - 45 mg/kg/day are sufficient to eradicate most staphylococcal infections. Lysostaphin is also effective against bacteria of this type which have developed resistance to conventional antibiotics such as penicillins and vancomycin. Lysostaphin analogues, such as variants and related enzymes, show similar activity.

6028051, Feb 22, 2000

Aug 27, 1998

9/140732

Michael W. Climo - Richmond VA
Gordon L. Archer - Richmond VA
Beth P. Goldstein - Tarrytown NY

Ambi Inc. - Tarrytown NY

A61K 3800, A61K 3170

514 2

Lysostaphin is an effective antibiotic in the treatment of staphylococcal infection. Large doses of lysostaphin or lysostaphin analogues are effective in short course, or even one dose administrations, in treating and eradicating staphylococcal infections, including those resistant to conventional antibiotics.