Inventors:
Donna L. Mendrick - Gaithersburg MD, US
Mark W. Porter - Gaithersburg MD, US
Kory R. Johnson - Gaithersburg MD, US
Brandon Higgs - Gaithersburg MD, US
Arthur L. Castle - Gaithersburg MD, US
Michael Orr - Gaithersburg MD, US
Michael R. Elashoff - Gaithersburg MD, US
International Classification:
C12Q 1/68
Abstract:
The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.