MICHAEL V SIVAK, MD
Osteopathic Medicine at Euclid Ave, Cleveland, OH

6615072, Sep 2, 2003

May 21, 1999

09/315982

Joseph A. Izatt - Pepper Pike OH
Michael V. Sivak - Cleveland Heights OH
Andrew Rollins - Bedford OH
Akihiro Horii - Hachiouji, JP
Tadashi Hirata - Hachioji, JP
Shuhei Iizuka - Hachioji, JP
Jiro Narita - Tokyo, JP

Olympus Optical Co., Ltd. - Tokyo

A61B 600

600478

An Optical Coherence Tomography (OCT) device irradiates a biological tissue with low coherence light, obtains a high resolution tomogram of the inside of the tissue by low-coherent interference with scattered light from the tissue, and is provided with an optical probe which includes an optical fiber having a flexible and thin insertion part for introducing the low coherent light. When the optical probe is inserted into a blood vessel or a patients body cavity, the OCT enables the doctor to observe a high resolution tomogram. In a optical probe, generally, a fluctuation of a birefringence occurs depending on a bend of the optical fiber, and this an interference contrast varies depending on the condition of the insertion. The OCT of the present invention is provided with polarization compensation means such as a Faraday rotator on the side of the light emission of the optical probe, so that the OCT can obtain the stabilized interference output regardless of the state of the bend.

6564089, May 13, 2003

Mar 5, 2002

10/087907

Joseph A. Izatt - Pepper Pike OH
Michael V. Sivak - Cleveland Heights OH
Andrew Rollins - Bedford OH
Akihiro Horii - Hachiouji, JP
Tadashi Hirata - Hachioji, JP
Shuhei Iizuka - Hachioji, JP

University Hospital of Cleveland - Cleveland OH
Olympus Optical Co., Ltd. - Tokyo

A61B 600

600478

An Optical Coherence Tomography (OCT) device irradiates a biological tissue with low coherence light, obtains a high resolution tomogram of the inside of the tissue by low-coherent interference with scattered light from the tissue, and is provided with an optical probe which includes an optical fiber having a flexible and thin insertion part for introducing the low coherent light. When the optical probe is inserted into a blood vessel or a patients body cavity, the OCT enables the doctor to observe a high resolution tomogram. In a optical probe, generally, a fluctuation of a birefringence occurs depending on a bend of the optical fiber, and this an interference contrast varies depending on the condition of the insertion. The OCT of the present invention is provided with polarization compensation means such as a Faraday rotator on the side of the light emission of the optical probe, so that the OCT can obtain the stabilized interference output regardless of the state of the bend.

6735463, May 11, 2004

Dec 21, 1999

09/468674

Joseph A. Izatt - Cleveland OH 44106-5066
Manish D. Kulkarni - Cleveland OH 44106-5066
Siavash Yazdanfar - Cleveland OH 44106-5066
Andrew Rollins - Cleveland OH 44106-5066
Michael V. Sivak - Cleveland OH 44106-5066

A61B 502

600476

A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent positions of scatterers in the sample; (c) processing the cross-correlation data to produce a velocity value and location of a moving scatterer in the sample; (d) assigning a color to the velocity value; and (f) merging the color into the grayscale image, at a point in the grayscale image indicative of the moving scatterers location, to produce a velocity-indicating, tomographic image. Preferably a first color is assigned for a positive velocity value and a second color is assigned for a negative velocity value.

5994690, Nov 30, 1999

Mar 17, 1998

9/040128

Manish D. Kulkarni - Cleveland OH
Joseph A. Izatt - Cleveland OH
Michael V. Sivak - Cleveland OH

H01J 314

250216

The present invention provides an improved optical coherence tomography system and involves estimating the impulse response (which is indicative of the actual reflecting and scattering sites within a tissue sample) from the output interferometric signal of an interferometer according to the following steps: (a) acquiring auto-correlation data from the interferometer system; (b) acquiring cross-correlation data from the interferometer system having the biological tissue sample in the sample arm; and (c) processing the auto-correlation data and the cross correlation data to produce an optical impulse response of the tissue. The impulse response may be obtained from the cross-correlation and auto-correlation data by: (d) obtaining an auto-power spectrum from the auto-correlation data by performing a Fourier transform on the auto-correlation data; (e) obtaining a cross-power spectrum from the cross-correlation data by performing a Fourier transform on the cross-correlation data; (f) obtaining a transfer function of the LSI system by taking a ratio of the cross-power spectrum to the auto-power spectrum; and (g) obtaining the optical impulse response of the LSI system by performing an inverse-Fourier transform on the transfer function. Preferably, coherent demodulation is used in combination with the above deconvolution technique to resolve closely-spaced reflecting sites in the sample. By utilizing both the magnitude and phase data of the demodulated interferometric signals, the OCT system of the present invention is able to distinguish between closely spaced reflecting sites within the sample.

6002480, Dec 14, 1999

Jun 2, 1998

9/088519

Joseph A. Izatt - Cleveland OH
Manish D. Kulkarni - Cleveland OH
Michael V. Sivak - Cleveland OH

G01B 902

356345

A method is described for determining depth-resolved backscatter characteristics of scatterers within a sample, comprising the steps of: acquiring a plurality of sets of cross-correlation interferogram data using an interferometer having a sample arm with the sample in the sample arm, wherein the sample includes a distribution of scatterers therein, and wherein the acquiring step includes the step of altering the distribution of scatterers within the sample with respect to the sample arm for substantially each acquisition; and averaging, in the Fourier domain, the cross-correlation interferogram data, thereby revealing backscattering characteristics of the scatterers within the sample.

6006128, Dec 21, 1999

Jun 2, 1998

9/088562

Joseph A. Izatt - Cleveland OH
Manish D. Kulkarni - Cleveland OH
Siavash Yazdanfar - Cleveland OH
Andrew Rollins - Cleveland OH
Michael V. Sivak - Cleveland OH

A61B 502

600476

A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent positions of scatterers in the sample; (c) processing the cross-correlation data to produce a velocity value and location of a moving scatterer in the sample; (d) assigning a color to the velocity value; and (f) merging the color into the grayscale image, at a point in the grayscale image indicative of the moving scatterer's location, to produce a velocity-indicating, tomographic image. Preferably a first color is assigned for a positive velocity value and a second color is assigned for a negative velocity value.

RE42641, Aug 23, 2011

Dec 14, 2001

10/020041

Joseph A. Izatt - Raleigh NC, US
Manish D. Kulkarni - San Ramon CA, US
Michael V. Sivak - Cleveland Heights OH, US

Case Western Reserve University - Cleveland OH

G01B 9/02

356497

A method is described for determining depth-resolved backscatter characteristics of scatterers within a sample, comprising the steps of: acquiring a plurality of sets of cross-correlation interferogram data using an interferometer having a sample arm with the sample in the sample arm, wherein the sample includes a distribution of scatterers therein, and wherein the acquiring step includes the step of altering the distribution of scatterers within the sample with respect to the sample arm for substantially each acquisition; and averaging, in the Fourier domain, the cross-correlation interferogram data, thereby revealing backscattering characteristics of the scatterers within the sample.

4350148, Sep 21, 1982

Jan 28, 1981

6/229155

Michael V. Sivak - Cleveland Heights OH
George J. Skipper - Chagrin Falls OH

Cleveland Clinic Foundation - Cleveland OH

A61B 100

128 4

An injector is disclosed for treating esophageal varices and other disorders with injected medications. The injector includes a needle which has a tubular bore for injecting the medication into the varices. The needle has an exposed length which is sufficiently long to enter a vein wall but not sufficiently long to pass through the vein and esophagus walls. A tubular connector has an internal bore connected with the needle and has a flange for inhibiting the connector from following the needle through a puncture. The tubular connector has a shank portion which is connected with a flexible tube. The flexible tube, tubular connector, and needle are slidingly receivable in a biopsy channel of a flexible, fiberoptic endoscope. A syringe is connected to the other end of the flexible tube for selectively forcing medications through the tube, connector, and needle into the varices.