Inventors:
Michael V. Muench - Point Pleasant NJ, US
Lori L. Muench - Point Pleasant NJ, US
Steven M. Feld - Loch Arbour (Allenhurst) NJ, US
International Classification:
A61K 38/43, A61K 31/714, A61K 31/675, A61K 31/525, A61K 31/4415, A61K 31/405, A61K 31/375, A61K 31/415, A61K 31/198, A61K 31/192, A61K 31/616
US Classification:
424 941, 424702, 424643, 514 52, 514165, 514251, 514 89, 514350, 514458, 514763, 514562, 514474, 514419, 514406, 514570
Abstract:
Preeclampsia and intrauterine growth restriction in a pregnant female mammal are prevented or decreased in severity by administering thereto a combination of a vitamin compound containing B1, Folic Acid (or active form 5-Methyl-Tetrahydrofolate i.e.; Metafolin®), B 6 (Pyridoxine or active form Pyridoxine 5-Phosphate P5P), B 12, Ascorbic Acid, Selenium, Zinc, Co-enzyme Q 10 and N-Acytyl Cysteine, Lycopene, optionally in further combination with Melatonin and/or Vitamin E or/and ASA 81 mg both of later, are cyclooxygenase inhibitors, a PGI.sub.2-mimetic, a thromboxane (TXA.sub.2) inhibitor, a compound possessing TXA.sub.2-agonistic and TXA.sub.2-inhibiting properties, a compound possessing TXA.sub.2-antagonistic and PGI.sub.2-mimetic activities, and a TXA.sub.2 antagonist.