Inventors:
Suzanne Benedict - Carlsbad CA, US
Michael Bennett - San Diego CA, US
Sacha Ninkovic - Carlsbad CA, US
Min Teng - San Diego CA, US
Yuanjin Rui - San Diego CA, US
Fen Wang - San Diego CA, US
Yong Wang - San Diego CA, US
Jinjiang Zhu - San Diego CA, US
Assignee:
Agouron Pharmaceuticals Inc. - San Diego CA
International Classification:
A61K031/551, C07D487/02
US Classification:
514220, 540495, 540488, 514211
Abstract:
Protein kinase, such as CHK-1, inhibiting tricyclic compounds of the following formula (wherein R, Rand Rare as defined in the specification)
pharmaceutical compositions containing effective amounts of said compounds or their salts are useful as a single agent or in combination with an anti-neoplastic agent or therapeutic radiation having an anti-neoplastic effect for treating diseases or conditions such as cancers.