Inventors:
Michael A. Teitell - Tarzana CA, US
Carla M. Koehler - Los Angeles CA, US
Geng Wang - Los Angeles CA, US
International Classification:
A61K 31/7088, C12N 15/63, C12N 5/10, A61P 25/08, C07H 21/02, C07H 21/04, A61P 43/00, C12N 1/00, C12N 1/19
US Classification:
514 44 R, 4353171, 4353201, 435369, 4352542, 435354, 536 231
Abstract:
Disclosed herein recombinant and/or isolated nucleic acid molecules which comprise, consist essentially of, or consist of a first nucleic acid sequence, which is a wild-type sequence or an altered sequence, directly or indirectly linked to a second nucleic acid sequence selected from the group consisting of: (1) a mitochondria localization sequence, (2) an RNA import sequence, or (3) a combination thereof, and methods of using thereof.