MICHAEL T WEST
Funeral Home and Crematory in Boston, MA

2002017, Nov 21, 2002

Mar 25, 2002

10/103806

Michael West - Boston MA, US
Jose Cibelli - Holden MA, US

A01K067/027

800/015000, 800/021000, 800/019000

The present invention concerns the use of chromosomal replacement techniques in the context of producing cloned and transgenic animals, in order to correct chromosome abnormalities or alter autosomal genotypes, and provide for novel breeding pairs by replacing the sex chromosome in animals to be cloned. Replacement of a sex chromosome, or an X or Y chromosome, will result in animals that are autosomally isogenic and sexually non-isogenic (AISN), with “autosomally isogenic” meaning that the paired sets of autosomes (non-sex chromosomes) in each animal are isogenic or identical. Also included in the invention are animals that are both “autosomally” and “allelically” isogenic whereby each particular pair of chromosomes is internally isogenic or identical within a single animal as well as between animals. Such animals are particularly useful in generating a line of cloned mammals using sexual reproduction, without having to undergo nuclear transfer in order to propagate cloned animals.

2005015, Jul 14, 2005

Sep 23, 2004

10/948841

Robert Lanza - Clinton MA, US
Michael West - Boston MA, US

Advanced Cell Technology, Inc. - Worcester MA

C12N005/08

435366000

The invention is concerned with producing differentiated cells, tissues and organs from pluripotent and mutlipotent cells. The methods of the invention are particularly useful for producing differentiated cells from pluripotent cells wherein communication between the cells of more than one embryonic germ layer or more than one organ system are required for development along a specific cell lineage. The invention methods are effected by in vivo or in vitro culturing of embryonic and developing or developed allogeneic or xenogeneic cells.

2005025, Nov 17, 2005

Mar 9, 2005

11/079930

Michael West - Boston MA, US
Robert Lanza - Clinton MA, US
Jose Cibelli - Holden MA, US

C12Q001/68, C12N015/63, C12N005/08, C12N015/85

435455000, 435366000

This invention relates to methods for rejuvenating normal somatic cells and for making normal somatic cells of a different type having the same genotype as a normal somatic cell of interest. These cells have particular application in cell and tissue transplantation. Also encompassed are methods of re-cloning cloned animals, particularly methods where the offspring of cloned mammals are designed to be genetically altered in comparison to their cloned parent, e.g., that are “hyper-young.” These animals should be healthier and possess desirable properties relative to their cloned parent. Also included are methods for activating endogenous telomerase, EPC-1 activity, and or the ALT pathway and/or extending the life-span of a normal somatic cell, and other genes associated with cell aging and proliferation capacity.

2004004, Feb 26, 2004

Jun 6, 2003

10/276001

Michael West - Boston MA, US

A01K067/027, G06F017/60

800/014000, 800/019000, 705/001000, 119/300000

This invention describes a novel method of agricultural animal production that provides animals with optimum growth characteristics in a reliable and cost-effective manner. The invention utilizes a novel combination of Nuclear Transfer (NT) and Embryonic Stem (ES) cell technologies that improves the efficiency of delivering optimized animals and facilitates the introduction of genetic modifications into farm animals.

2002004, Apr 18, 2002

Mar 5, 2001

09/797684

Robert Lanza - Clinton MA, US
Michael West - Boston MA, US

A01K067/00, A61K049/00

800/003000, 800/008000, 424/009200

This invention relates to methods for making immune compatible tissues and cells for the purpose of transplantation and tissue engineering, using the techniques of nuclear transfer and cloning. Also encompassed are methods for determining the effect on immune compatibility of expressed transgenes and other genetic manipulations of the engineered cells and tissues.