MICHAEL T GROSS
Physical Therapy at University Dr, Durham, NC
License number
Florida 2660
Issued Date
Mar 28, 1980
Effective Date
Jan 1, 1901
Expiration Date
Dec 31, 1986
Category
Health Care
Type
Physical Therapist
Address
Address
2101 University Dr, Durham, NC 27707
Personal information
See more information about MICHAEL T GROSS at radaris.comName
Address
Phone
4727 Beau Ct, Trinity, NC 27370
5026 Sedgewick Dr APT H, Raleigh, NC 27616
664 Braewick Rd, Tryon, NC 28782
11522 Winners Cir, Charlotte, NC 28215
138 Serendipity Ln, Troutman, NC 28166
Professional information
See more information about MICHAEL T GROSS at trustoria.com
Potassium Channel Inhibitors And Method
Potassium Channel Inhibitors And Method
US Patent:
6511977, Jan 28, 2003
Filed:
Sep 25, 2000
Appl. No.:
09/670285
Inventors:
John Lloyd - Yardley PA
Heather J. Finlay - Lawrenceville NJ
Wayne Vaccaro - Yardley PA
Karnail S. Atwal - Newtown PA
Michael F. Gross - Durham NC
Kerry L. Spear - Raleigh NC
Heather J. Finlay - Lawrenceville NJ
Wayne Vaccaro - Yardley PA
Karnail S. Atwal - Newtown PA
Michael F. Gross - Durham NC
Kerry L. Spear - Raleigh NC
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D491052
US Classification:
5142338, 51425214, 51425218, 51425304, 514302, 544127, 544331, 544362, 546115, 546116
Abstract:
Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure where A, B, D, Q, X , R, R , X and R are as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method is provided for preventing cardiac arrhythmia employing the above compounds.
Potassium Channel Inhibitors
Potassium Channel Inhibitors
US Patent:
6566380, May 20, 2003
Filed:
Jul 24, 2001
Appl. No.:
09/910817
Inventors:
Aimee Dolores Reed - Durham NC
Michael Francis Gross - Durham NC
Serge Beaudoin - Morrisville NC
Michael Francis Gross - Durham NC
Serge Beaudoin - Morrisville NC
Assignee:
ICAgen, Inc. - Durham NC
International Classification:
C07D21324
US Classification:
514357, 514400, 514256, 514365, 514397, 514602, 544335, 546337, 5483381, 548204, 5483151, 564 84
Abstract:
Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.
Pyrazolopyrimidine Compositions
Pyrazolopyrimidine Compositions
US Patent:
7098335, Aug 29, 2006
Filed:
Nov 12, 2004
Appl. No.:
10/987089
Inventors:
Robert N. Atkinson - Raleigh NC, US
Michael F. Gross - Durham NC, US
Albert M. van Rhee - Durham NC, US
Michael F. Gross - Durham NC, US
Albert M. van Rhee - Durham NC, US
Assignee:
Icagen, Inc. - Durham NC
International Classification:
C07D 487/00, A61K 31/519
US Classification:
544281, 544280, 5142593
Abstract:
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazolopyrimidines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
Pyrazole-Amides And -Sulfonamides
Pyrazole-Amides And -Sulfonamides
US Patent:
2008006, Mar 13, 2008
Filed:
Apr 26, 2007
Appl. No.:
11/740845
Inventors:
Robert Atkinson - Raleigh NC, US
Michael Gross - Durham NC, US
Michael Gross - Durham NC, US
Assignee:
Icagen, Inc. - Research Triangle Park NC
International Classification:
A61K 31/541, A61K 31/415, A61K 31/4184, A61K 31/428, A61K 31/4427, A61K 31/4523, A61K 31/47, C07D 213/02, C07D 221/00, C12N 5/00, C07D 295/00, C07D 277/62, C07D 241/10, C07D 239/24, C07D 237/06, C07D 235/04, C07D 231/10, C07D 217/00, A61P 25/00, A61K 31/496, A61K 31/497, A61K 31/501, A61K 31/506, A61K 31/5377
US Classification:
514227800, 435375000, 514236500, 514252050, 514254050, 514255050, 514256000, 514307000, 514326000, 514341000, 514367000, 514394000, 514406000, 514407000, 544140000, 544238000, 544333000, 544371000, 544405000, 544060000, 546139000, 546211000, 546275400, 548159000, 548306100, 548364100, 548365100, 548371400, 548374100
Abstract:
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazole-amides and -sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
Potassium Channel Inhibitors And Method
Potassium Channel Inhibitors And Method
US Patent:
6150356, Nov 21, 2000
Filed:
Aug 17, 1999
Appl. No.:
9/375955
Inventors:
John Lloyd - Yardley PA
Heather J. Finlay - Lawrenceville NJ
Wayne Vaccaro - Yardley PA
Karnail S. Atwal - Newtown PA
Michael F. Gross - Durham NC
Kerry L. Spear - Raleigh NC
Heather J. Finlay - Lawrenceville NJ
Wayne Vaccaro - Yardley PA
Karnail S. Atwal - Newtown PA
Michael F. Gross - Durham NC
Kerry L. Spear - Raleigh NC
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D21542, C07D31168, A61K 31352
US Classification:
514218
Abstract:
Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure ##STR1## where A, B, D, Q, X. sup. 1, R, R. sup. 1, X. sup. 2 and R. sup. 2 are as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method is provided for preventing cardiac arrhythmia employing the above compounds.
Cycloalkyl Inhibitors Of Potassium Channel Function
Cycloalkyl Inhibitors Of Potassium Channel Function
US Patent:
7202253, Apr 10, 2007
Filed:
Nov 24, 2004
Appl. No.:
10/997734
Inventors:
John Lloyd - Yardley PA, US
Yoon T. Jeon - Belle Meade NJ, US
Heather Finlay - Skillman NJ, US
Lin Yan - East Brunswick NJ, US
Michael F. Gross - Durham NC, US
Serge Beaudoin - Morrisville NC, US
Yoon T. Jeon - Belle Meade NJ, US
Heather Finlay - Skillman NJ, US
Lin Yan - East Brunswick NJ, US
Michael F. Gross - Durham NC, US
Serge Beaudoin - Morrisville NC, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
Icagen, Inc. - Durham NC
Icagen, Inc. - Durham NC
International Classification:
A61K 31/4709, A61K 31/519, C07D 217/22, C07D 239/84, C07D 471/06
US Classification:
5142664, 514300, 514310, 544293, 546122, 546143
Abstract:
Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the K1 subfamily of voltage gated K channels, especially inhibitors K1. 5 which has been linked to the ultra-rapidly activating delayed rectifier K current I), methods of using such compounds in the prevention and treatment of arrhythmia and I-associated conditions, and pharmaceutical compositions containing such compounds.
Potassium Channel Inhibitors And Method
Potassium Channel Inhibitors And Method
US Patent:
2004005, Mar 25, 2004
Filed:
Nov 15, 2002
Appl. No.:
10/295574
Inventors:
John Lloyd - Yardley PA, US
Heather Finlay - Lawrenceville NJ, US
Wayne Vaccaro - Yardley PA, US
Karnail Atwal - Newtown PA, US
Michael Gross - Durham NC, US
Kerry Spear - Raleigh NC, US
Heather Finlay - Lawrenceville NJ, US
Wayne Vaccaro - Yardley PA, US
Karnail Atwal - Newtown PA, US
Michael Gross - Durham NC, US
Kerry Spear - Raleigh NC, US
International Classification:
A61K031/496, A61K031/506, A61K031/427, A61K031/422, A61K031/4196, A61K031/4178, C 07D 4 5/02
US Classification:
514/252200, 514/254110, 514/456000, 514/378000, 514/444000, 514/422000, 514/383000, 514/363000, 514/364000, 514/370000, 514/407000, 514/397000, 514/275000, 544/295000, 544/331000, 544/376000, 548/138000, 548/143000, 548/181000, 548/245000, 548/266200, 548/311400, 548/364400, 549/404000
Abstract:
Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure
where A, B, D, Q, X, R, R, Xand Rare as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method is provided for preventing cardiac arrhythmia employing the above compounds.
Cycloalkyl Inhibitors Of Potassium Channel Function
Cycloalkyl Inhibitors Of Potassium Channel Function
US Patent:
2004007, Apr 15, 2004
Filed:
Jan 31, 2003
Appl. No.:
10/356158
Inventors:
John Lloyd - Yardley PA, US
Yoon Jeon - Belle Meade NJ, US
Heather Finlay - Skillman NJ, US
Lin Yan - East Brunswick NJ, US
Michael Gross - Durham NC, US
Serge Beaudoin - Morrisville NC, US
Yoon Jeon - Belle Meade NJ, US
Heather Finlay - Skillman NJ, US
Lin Yan - East Brunswick NJ, US
Michael Gross - Durham NC, US
Serge Beaudoin - Morrisville NC, US
International Classification:
A61K031/433, A61K031/4245, A61K031/325, A61K031/4172, A61K031/255, A61K031/17
US Classification:
514/362000, 514/364000, 514/517000, 514/484000, 514/512000, 514/601000, 514/588000, 514/593000, 548/134000, 548/125000, 558/047000, 558/260000, 560/115000, 564/039000, 564/040000, 564/080000, 514/401000
Abstract:
Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the K1 subfamily of voltage gated K channels, especially inhibitors K1.5 which has been linked to the ultra-rapidly activating delayed rectifier K current I), methods of using such compounds in the prevention and treatment of arrhythmia and I-associated conditions, and pharmaceutical compositions containing such compounds.
Pyrazole-Amides And -Sulfonamides
Pyrazole-Amides And -Sulfonamides
US Patent:
7223782, May 29, 2007
Filed:
Nov 1, 2002
Appl. No.:
10/286304
Inventors:
Robert N. Atkinson - Raleigh NC, US
Michael F. Gross - Durham NC, US
Michael F. Gross - Durham NC, US
Assignee:
Icagen, Inc. - Research Triangle Park NC
International Classification:
A61K 31/4155, C07D 231/12, C07D 231/14
US Classification:
514406, 5483741
Abstract:
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazole-amides and -sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
Potassium Channel Inhibitors
Potassium Channel Inhibitors
US Patent:
6849634, Feb 1, 2005
Filed:
Dec 7, 2001
Appl. No.:
10/004867
Inventors:
Serge Beaudoin - Morrisvile NC, US
Aimee D. Reed - Willoughby OH, US
Michael F. Gross - Durham NC, US
Aimee D. Reed - Willoughby OH, US
Michael F. Gross - Durham NC, US
Assignee:
ICAgen - Durham NC
International Classification:
A61K 3118, C07C31107
US Classification:
514256, 514249, 5142581, 514275, 514278, 514299, 514388, 514398, 514399, 514471, 514472, 514601, 514602, 514605, 544230, 544235, 544253, 544316, 544332, 544335, 544349, 546 18, 546112, 546304, 546314, 5483331, 5483355, 549480, 549492, 564 80, 564 92
Abstract:
Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.