MICHAEL STADLER
Pilots at York St, San Francisco, CA
License number
California A5228410
Issued Date
Feb 2015
Expiration Date
Feb 2020
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
1519B York St, San Francisco, CA 94110
Professional information
Student At Stanford University School Of Medicine
Location:
San Francisco Bay Area
Industry:
Biotechnology
Education:
Stanford University School of Medicine 2007 - 2012
Student At Stanford University School Of Medicine
Location:
San Francisco Bay Area
Industry:
Biotechnology
Education:
Stanford University School of Medicine 2007 - 2012
Translation Kinetic Mapping, Modification And Harmonization
US Patent:
2013014, Jun 13, 2013
Filed:
Oct 30, 2012
Appl. No.:
13/664252
Inventors:
The Board of Trustees of the Leland Stanford Junio - Palo Alto CA, US
The University of Texas Medical Branch at Galvest - Galveston TX, US
Paige S. Spencer - Galveston TX, US
Michael Stadler - San Francisco CA, US
The University of Texas Medical Branch at Galvest - Galveston TX, US
Paige S. Spencer - Galveston TX, US
Michael Stadler - San Francisco CA, US
Assignee:
The University of Texas Medical Branch at Galveston - Galveston TX
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
C07H 21/02
US Classification:
435 61, 536 253, 435 691, 536 231, 435 681
Abstract:
The profile of translation elongation rate along an mRNA is modulated in a directed manner by locally altering codon usage, in particular utilizing differences in ribosomal dwell times among pairs of synonymous codons translated by a single tRNA through wobble base pairing. Unlike codon optimization based on organism-specific codon frequencies or tRNA pools, the methods of the invention need not change the tRNA that translates the codon, rather modulating the interaction between a given tRNA and the mRNA coding sequence.