MR. MICHAEL SIMPSON
Hearing Instrument Specialists at Peters Rd, Knoxville, TN

6649431, Nov 18, 2003

Feb 27, 2001

09/795660

Vladimir I. Merkulov - Knoxville TN
Douglas H. Lowndes - Knoxville TN
Michael A. Guillorn - Knoxville TN
Michael L. Simpson - Knoxville TN

UT. Battelle, LLC - Oak Ridge TN

H01L 2100

438 20, 438 70, 438 22, 313336, 445 49, 445 51, 257 13, 257 79, 423445 R, 423448

Systems and methods are described for carbon tips with expanded bases. A method includes producing an expanded based carbon containing tip including: fabricating a carbon containing expanded base on a substrate; and then fabricating a carbon containing fiber on the expanded base. An apparatus includes a carbon containing expanded base coupled to a substrate; and a carbon containing fiber coupled to said carbon containing expanded base.

4833394, May 23, 1989

Sep 1, 1988

7/239458

Michael L. Simpson - Knoxville TN

Oak Ridge Associated Universities, Inc. - Oak Ridge TN

G01N 2762

324 713

An apparatus for producing a signal that is representative of the profile of an ion beam and compensates for the system noise of the ion beam profile scanner includes an ion beam profile scanner which produces a beam profile signal that is proportional to the profile of the ion beam and that has system noise from the scanner. A reference signal is produced which has a frequency proportional to the scan frequency of the beam profile signal, and at least one harmonic of the reference signal is also produced. The reference signal and at least one harmonic of the reference signal are individually adjusted in phase and amplitude to match the system noise in the beam profile signal, and the two adjusted signals are subtracted from the beam profile signal in a summation circuit. The resulting signal is representative of the beam profile and has reduced noise as compared to the beam profile signal.

4878014, Oct 31, 1989

Sep 1, 1988

7/239454

Michael L. Simpson - Knoxville TN

Oak Ridge Associated Universities - Oak Ridge TN

G01N 2700

324 713

A beam profile scanner includes a probe constructed of a material that will emit electrons when struck by a particle beam such as an ion beam. The probe is passed through the ion beam and the electrons emitted by the probe are detected when they strike a detector surface that is configured and oriented to offer a substantially symmetric view to the moving probe in order to minimize changing capacitance noise. The detector surface is electrically connected to an analyzer circuit that monitors and further processes the current caused by electrons striking the dectector surface and that generates a signal corresponding to the ion beam profile. In the preferred embodiment, the detector surface is a circular metal plate charged to attract electrons emitted by the probe, and the symmetric view of the surface with respect to the probe helps to maintain noise at an acceptably low level. Also, preferably, a preamplifier is connected to and mounted proximate to the detector surface in a vacuum within a detector housing, and both the detector surface, amplifier and probe are disposed inside a grounded shield structure.

7408186, Aug 5, 2008

Mar 24, 2005

11/089099

Vladimir I. Merkulov - Knoxville TN, US
Anatoli V. Melechko - Knoxville TN, US
Michael A. Guillorn - Knoxville TN, US
Douglas H. Lowndes - Knoxville TN, US
Michael L. Simpson - Knoxville TN, US

UT-Battelle LLC - Oak Ridge TN

H01L 21/00

257 40, 257 17, 977843, 977943

Systems and methods are described for controlled alignment of catalyticaly grown nanostructures in a large-scale synthesis process. A composition includes an elongated nanostructure including a first segment defining a first axis and a second segment coupled to the first segment, the second segment defining a second axis that is substantially nonparallel to the first axis. A method includes: generating an electric field proximate an edge of a protruding section of an electrode, the electric field defining a vector; and forming an elongated nanostructure located at a position on a surface of a substrate, the position on the surface of the substrate proximate the edge of the protruding section of the electrode, at least one tangent to the elongated nanostructure i) substantially parallel to the vector defined by the electric field and ii) substantially non-parallel to a normal defined by the surface of the substrate.

6117643, Sep 12, 2000

Nov 25, 1997

8/978439

Michael L. Simpson - Knoxville TN
Gary S. Sayler - Blaine TN
Michael J. Paulus - Knoxville TN

UT Battelle, LLC - Oak Ridge TX
The University of Tennessee Research Corp. - Knoxville TX

G01N 3353

435 71

Disclosed are monolithic bioelectronic devices comprising a bioreporter and an OASIC. These bioluminescent bioreporter integrated circuit are useful in detecting substances such as pollutants, explosives, and heavy-metals residing in inhospitable areas such as groundwater, industrial process vessels, and battlefields. Also disclosed are methods and apparatus for environmental pollutant detection, oil exploration, drug discovery, industrial process control, and hazardous chemical monitoring.

7090992, Aug 15, 2006

Jun 14, 2005

11/152138

Michael L. Simpson - Knoxville TN, US
Michael J. Paulus - Knoxville TN, US
Gary S. Sayler - Blaine TN, US
Bruce M. Applegate - West Lafayette IN, US
Steven A. Ripp - Knoxville TN, US

UT-Battelle, LLC - Oak Ridge TN

G01N 33/554

435 732, 422 55, 422 57, 422 28, 422 8201, 422 8205, 422 8206, 422 8207, 422 8208, 4352871, 4352877, 435808, 4352872, 436805

Bioelectronic devices for the detection of estrogen include a collection of eukaryotic cells which harbor a recombinant lux gene from a high temperature microorganism wherein the gene is operably linked with a heterologous promoter gene. A detectable light-emitting lux gene product is expressed in the presence of the estrogen and detected by the device.

6905834, Jun 14, 2005

Sep 12, 2000

09/660581

Michael L. Simpson - Knoxville TN, US
Michael J. Paulus - Knoxville TN, US
Gary S. Sayler - Knoxville TN, US
Bruce M. Applegate - Knoxville TN, US
Steven A. Ripp - Knoxville TN, US

UT-Battelle, LLC - Oak Ridge TN

G01N033/554

435 732, 422 55, 422 57, 422 58, 422 8201, 422 8205, 422 8206, 422 8207, 422 8208, 4352871, 4352872, 4352887, 435808, 436805

Disclosed are monolithic bioelectronic devices comprising a bioreporter and an OASIC. These bioluminescent bioreporter integrated circuit are useful in detecting substances such as pollutants, explosives, and heavy-metals residing in inhospitable areas such as groundwater, industrial process vessels, and battlefields. Also disclosed are methods and apparatus for detection of particular analytes, including ammonia and estrogen compounds.

8343766, Jan 1, 2013

Nov 28, 2011

13/305134

Timothy E. McKnight - Greenback TN, US
Anatoli V. Melechko - Oak Ridge TN, US
Michael L. Simpson - Knoxville TN, US

UT-Battle, LLC - Oak Ridge TN

C12N 15/87

435459, 435466, 435470

A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of biological cells. The method and apparatus include introducing a compartmentalized extracellular component fixedly attached to a cellular penetrant structure to the intracellular domain of the cell, wherein the cell is fixed in a predetermined location and wherein the component is expressed within in the cell while being retained within the compartment and wherein the compartment restricts the mobility and interactions of the component within the cell and prevents transference of the component to the cell.

8101388, Jan 24, 2012

Sep 28, 2007

11/904862

Timothy E. McKnight - Greenback TN, US
Anatoli V. Melechko - Oak Ridge TN, US
Michael L. Simpson - Knoxville TN, US

UT-Battelle, LLC - Oak Ridge TN

C12N 13/00, C12P 1/00, C12P 21/00, C12M 1/00

4351734, 435267, 4352831, 435 703

The present invention in one embodiment provides a method for extracting molecular material including providing a probe comprising a penetration portion having a nanoscale surface for penetrating a biological compartment, a receptor present on the penetrating portion of the probe, wherein the receptor has an affinity for a target molecular material from the biological compartment; inserting the probe into the biological compartment, the receptor present on the penetrating portion of the probe engages the target molecular material; and extracting the probe and the target molecular material engaged to the inserting portion of the probe from the biological compartment.