Inventors:
Henrik Sune Andersen - Lyngby, DK
Thomas Kruse Hansen - Herlev, DK
Jesper Lau - Farum, DK
Niels Peter Hundahl Moller - Kobenhavn O, DK
Ole Hvilsted Olsen - Bronshoj, DK
Frank Urban Axe - Escondido CA
Farid Bakir - San Diego CA
Yu Ge - San Diego CA
Daniel Dale Holsworth - San Diego CA
Luke Milburn Judge - Seattle WA
Michael James Newman - San Diego CA
Roy Teruyuki Uyeda - San Diego CA
Barry Zvi Shapira - Acton CA
Assignee:
Novo Nordisk A/S - Bagsvaerd
International Classification:
C07D47102
Abstract:
The present invention provides novel thienopyridines, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) including PTP1B, T cell PTP, wherein X, R , R , R , and R are defined more fully in the description. The compounds are useful in the treatment of type 1 diabetes, type 2 diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.