DR. MICHAEL S HERSHFIELD, M.D.
Osteopathic Medicine at Roxboro St, Durham, NC
License number
North Carolina 21274
Category
Osteopathic Medicine
Type
Rheumatology
Address
Address
4101 N Roxboro St, Durham, NC 27704
Phone
(919) 684-8111
Personal information
See more information about MICHAEL S HERSHFIELD at radaris.comName
Address
Phone
4019 Bristol Rd, Durham, NC 27707
4019 Bristol Rd, Durham, NC 27707
Durham, NC
Organization information
See more information about MICHAEL S HERSHFIELD at bizstanding.comMichael S Hershfield MD
Building Research Dr, Durham, NC 27710
Categories:
Rheumatology Physicians & Surgeons
Site:
Phone:
(919) 684-4184 (Phone)
Professional information
Michael Hershfield, Durham NC
Specialties:
Clinical & Laboratory Immunology, Rheumatology
Work:
Durham Va Medical Center
508 Fulton St, Durham, NC 27705
508 Fulton St, Durham, NC 27705
Education:
University of Pennsylvania(1967)
Peg-Urate Oxidase Conjugates And Use Thereof
US Patent:
6576235, Jun 10, 2003
Filed:
Aug 6, 1999
Appl. No.:
09/370084
Inventors:
L. David Williams - Fremont CA
Michael S. Hershfield - Durham NC
Susan J. Kelly - Chapel Hill NC
Mark G. P. Saifer - San Carlos CA
Merry R. Sherman - San Carlos CA
Michael S. Hershfield - Durham NC
Susan J. Kelly - Chapel Hill NC
Mark G. P. Saifer - San Carlos CA
Merry R. Sherman - San Carlos CA
Assignee:
Mountain View Pharmaceuticals, Inc. - Menlo Park CA
Duke University - Durham NC
Duke University - Durham NC
International Classification:
A61K 3844
US Classification:
424 944, 435189, 435191, 4352523, 4353201, 536 232, 530350
Abstract:
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
Michael S Hershfield, Durham NC
Specialties:
Rheumatologist
Address:
4101 N Roxboro St, Durham, NC 27704
Peg-Urate Oxidase Conjugates And Use Thereof
US Patent:
7927589, Apr 19, 2011
Filed:
Aug 3, 2007
Appl. No.:
11/833590
Inventors:
L. David Williams - Fremont CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
Mark G. P. Saifer - San Carlos CA, US
Merry R. Sherman - San Carlos CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
Mark G. P. Saifer - San Carlos CA, US
Merry R. Sherman - San Carlos CA, US
Assignee:
Mountain View Pharmaceuticals, Inc. - Menlo Park CA
International Classification:
A61K 38/44, C12N 9/02, C12N 9/06
US Classification:
424 944, 424 943, 435181, 435188, 435189, 435191
Abstract:
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
Peg-Urate Oxidase Conjugates And Use Thereof
US Patent:
7723089, May 25, 2010
Filed:
Apr 19, 2001
Appl. No.:
09/839946
Inventors:
L. David Williams - Fremont CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
Mark G. P. Saifer - San Carlos CA, US
Merry R. Sherman - San Carlos CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
Mark G. P. Saifer - San Carlos CA, US
Merry R. Sherman - San Carlos CA, US
Assignee:
Mountain View Pharmaceuticals, Inc. - Menlo Park CA
Duke University - Durham NC
Duke University - Durham NC
International Classification:
C12N 9/04, C12N 9/06
US Classification:
435190, 435191, 435440, 536 232
Abstract:
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
Aggregate-Free Urate Oxidase For Preparation Of Non-Immunogenic Polymer Conjugates
US Patent:
2011028, Nov 24, 2011
Filed:
Apr 13, 2011
Appl. No.:
13/085793
Inventors:
Merry R. Sherman - San Carlos CA, US
Mark G.P. Saifer - San Carlos CA, US
L. David Williams - Fremont CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
Mark G.P. Saifer - San Carlos CA, US
L. David Williams - Fremont CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
International Classification:
C12Q 1/26
US Classification:
435 25
Abstract:
A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.
Peg-Urate Oxidase Conjugates And Use Thereof
US Patent:
2012014, Jun 14, 2012
Filed:
Nov 29, 2011
Appl. No.:
13/306336
Inventors:
L. David Williams - Fremont CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
Mark G.P. Saifer - San Carlos CA, US
Merry R. Sherman - San Carlos CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
Mark G.P. Saifer - San Carlos CA, US
Merry R. Sherman - San Carlos CA, US
Assignee:
Duke University - Durham NC
Mountain View Pharmaceuticals, Inc. - Menlo Park CA
Mountain View Pharmaceuticals, Inc. - Menlo Park CA
International Classification:
C12N 9/96, C12N 9/06
US Classification:
435188, 435191
Abstract:
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
Peg-Urate Oxidase Conjugates And Use Thereof
US Patent:
8618267, Dec 31, 2013
Filed:
Apr 8, 2011
Appl. No.:
13/083152
Inventors:
L. David Williams - Fremont CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
Mark G. P. Saifer - San Carlos CA, US
Merry R. Sherman - San Carlos CA, US
Michael S. Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
Mark G. P. Saifer - San Carlos CA, US
Merry R. Sherman - San Carlos CA, US
Assignee:
Mountain View Pharmaceuticals, Inc. - Menlo Park CA
Duke University - Durham NC
Duke University - Durham NC
International Classification:
A61K 38/44, C12N 9/02
US Classification:
530412, 435189, 435190, 435191
Abstract:
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
Urate Oxidase
US Patent:
7056713, Jun 6, 2006
Filed:
Aug 5, 1999
Appl. No.:
09/762097
Inventors:
Michael Hershfield - Durham NC, US
Susan J. Kelly - Chapel Hill NC, US
Susan J. Kelly - Chapel Hill NC, US
Assignee:
Duke University - Durham NC
International Classification:
C12N 9/02, C12N 15/53
US Classification:
435189, 4352523, 4353201, 536 232
Abstract:
The present invention relates, in general, to urate oxidase (uricase) proteins and nucleic acid molecules encoding same. In particular, the invention relates to uricase proteins which are particularly useful as, for example, intermediates for making improved modified uricase proteins with reduced immunogenicity and increased bioavailability.
Urate Oxidase
US Patent:
2006018, Aug 24, 2006
Filed:
Feb 21, 2006
Appl. No.:
11/357028
Inventors:
Michael Hershfield - Durham NC, US
Susan Kelly - Chapel Hill NC, US
Susan Kelly - Chapel Hill NC, US
Assignee:
DUKE UNIVERSITY - Durham NC
International Classification:
C12N 9/06
US Classification:
435191000
Abstract:
The present invention relates, in general, to urate oxidase (uricase) proteins and nucleic acid molecules encoding same. In particular, the invention relates to uricase proteins which are particularly useful as, for example, intermediates for making improved modified uricase proteins with reduced immunogenicity and increased bioavailability.