Michael Rush Lerner
Physician in Dallas, TX
License number
Utah 374571-1205
Issued Date
Aug 12, 1999
Expiration Date
Apr 30, 2000
Category
Physician
Type
Physician & Surgeon
Address
Address
Dallas, TX
Professional information
Cell Surface Receptors For The Detection And Identification Of Compounds
US Patent:
6475733, Nov 5, 2002
Filed:
Oct 4, 2000
Appl. No.:
09/647653
Inventors:
Michael R. Lerner - Dallas TX
Assignee:
Lerner Pharmaceuticals, Inc. - Woodbridge CT
International Classification:
C12Q 168
US Classification:
435 6, 435 71, 435 691
Abstract:
The invention exploits the evolutionary principles responsible for the development of the broad spectrum general odorant detector system, to create a cell-surface receptor based system capable of detecting and discriminating between thousands of chemicals. This is accomplished by subjecting a defined set of cell-surface receptors such as G-protein coupled receptors, tyrosine kinase receptors, and/or ion channels, to the types of evolutionary forces that have created the array of approximately 1,000 natural receptors used in general olfaction by higher animals. This goal is further accomplished by a âdirected evolution-in-a-test-tubeâ method, imposing very high rates of mutation and extremely strict selection criteria to create a sensor. The novel sensor of the present invention is selected using a sensitive melanophore-based functional bioassay.