DR. MICHAEL R LIEBER, M.D.
Medical Practice at Eastlake Ave, Los Angeles, CA
License number
California G65451
Category
Medical Practice
Type
Anatomic Pathology
Address
Address
1441 Eastlake Ave, Los Angeles, CA 90089
Phone
(323) 865-0056
(323) 865-0568
(323) 865-0568
Personal information
See more information about MICHAEL R LIEBER at radaris.comName
Address
Phone
3578 Glen Ridge Dr, Chino Hills, CA 91709
245 W Palm Dr, Arcadia, CA 91007
1415 Camden Ave APT 408, Los Angeles, CA 90025
2050 Delaware St APT 303, Berkeley, CA 94709
205 W Kelly Rd, Newbury Park, CA 91320
Professional information
Dr. Michael J Lieber, Los Angeles CA - MD (Doctor of Medicine)
Specialties:
Critical Care Medicine, Pulmonology, Undersea & Hyperbaric Medicine
Address:
Gonda Center for Wnd Heal Hyper
200 Ucla Medical Plz SUITE B26529, Los Angeles 90095
(310) 794-9014 (Phone)
Lieber and Wu MD
2001 Santa Monica Blvd SUITE 1190W, Santa Monica 90404
(310) 453-1414 (Phone)
Lieber and Wu MDs
2001 Santa Monica Blvd SUITE 1190W, Santa Monica 90404
(310) 453-1414 (Phone)
200 Ucla Medical Plz SUITE B26529, Los Angeles 90095
(310) 794-9014 (Phone)
Lieber and Wu MD
2001 Santa Monica Blvd SUITE 1190W, Santa Monica 90404
(310) 453-1414 (Phone)
Lieber and Wu MDs
2001 Santa Monica Blvd SUITE 1190W, Santa Monica 90404
(310) 453-1414 (Phone)
Certifications:
Critical Care Medicine, 1987, Internal Medicine, 1978, Pulmonary Disease, 1980, Undersea & Hyperbaric Medicine, 2000
Awards:
Healthgrades Honor Roll
Languages:
English, Spanish
Education:
Medical School
David Geffen School Of Medicine At UCLA, University Of California, Los Angeles
Graduated: 1975
Harbor Genl Hospital
Graduated: 1976
Graduated: 1978
Graduated: 1980
David Geffen School Of Medicine At UCLA, University Of California, Los Angeles
Graduated: 1975
Harbor Genl Hospital
Graduated: 1976
Graduated: 1978
Graduated: 1980
Michael R Lieber, Los Angeles CA
Specialties:
Pathologist
Address:
1441 Eastlake Ave, Los Angeles, CA 90089
Education:
University of Chicago, Pritzker School of Medicine - Doctor of Medicine
Board certifications:
American Board of Pathology Certification in Anatomic Pathology (Pathology)
Professor At Usc
Position:
Professor at USC
Location:
Greater Los Angeles Area
Industry:
Research
Work:
USC
-
Professor
Dr. Michael R Lieber, Los Angeles CA - MD (Doctor of Medicine)
Specialties:
Anatomic Pathology
Address:
1441 Eastlake Ave SUITE 5428, Los Angeles 90089
(323) 865-0056 (Phone), (323) 865-3019 (Fax)
NORRIS CANCER CENTER
1441 Eastlake Ave, Los Angeles 90089
(323) 865-3359 (Phone), (323) 865-3000 (Fax)
(323) 865-0056 (Phone), (323) 865-3019 (Fax)
NORRIS CANCER CENTER
1441 Eastlake Ave, Los Angeles 90089
(323) 865-3359 (Phone), (323) 865-3000 (Fax)
Certifications:
Anatomic Pathology, 1987
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Center Of Chicago / Pritzker School Of Medicine
Nih Clin Ctr
National Institutes Of Health Clinical Center
Center Of Chicago / Pritzker School Of Medicine
Nih Clin Ctr
National Institutes Of Health Clinical Center
Novel Artemis/Dna-Dependent Protein Kinase Complex And Methods Of Use Thereof
US Patent:
2004000, Jan 8, 2004
Filed:
Feb 5, 2003
Appl. No.:
10/359360
Inventors:
Michael Lieber - Los Angeles CA, US
Yunmei Ma - Los Angeles CA, US
Ulrich Pannicke - Ulm, DE
Klaus Schwarz - Ulm, DE
Yunmei Ma - Los Angeles CA, US
Ulrich Pannicke - Ulm, DE
Klaus Schwarz - Ulm, DE
International Classification:
C12Q001/68, C12P019/34, C12N009/22
US Classification:
435/006000, 435/199000, 435/091200
Abstract:
In the present invention, it is disclosed that Artemis forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PK) in vitro and in vivo in the absence of DNA. The purified Artemis protein alone possesses single-strand specific 5′ to 3′ exonuclease activity. Upon complex formation, DNA-PKphosphorylates Artemis, and Artemis acquires endonucleolytic activity with respect to single-stranded nucleotides, including 5′ and 3′ overhangs, as well as hairpins. Further, the Artemis:DNA-PKcs complex can open hairpins generated by the RAG complex from a 12/23-substrate pair. Thus, DNA-PKregulates Artemis by both phosphorylation and complex formation to permit enzymatic activities that are critical for the hairpin opening step of V(D)J recombination and for all of the 5′ and 3′ overhang processing in nonhomologous DNA end joining.
Novel Artemis/Dna-Dependent Protein Kinase Complex And Methods Of Use Thereof
US Patent:
2009001, Jan 15, 2009
Filed:
Jun 12, 2008
Appl. No.:
12/138330
Inventors:
Michael R. Lieber - Los Angeles CA, US
Yunmei Ma - Los Angeles CA, US
Ulrich Pannicke - Ulm, DE
Klaus Schwarz - Ulm, DE
Yunmei Ma - Los Angeles CA, US
Ulrich Pannicke - Ulm, DE
Klaus Schwarz - Ulm, DE
Assignee:
University of Southern California - Los Angeles CA
International Classification:
A61K 39/395, C12N 9/16, C07H 19/00, A61P 35/00, C12Q 1/68, C12P 21/00
US Classification:
4241301, 435196, 536 553, 435 6, 435 691
Abstract:
In the present invention, it is disclosed that Artemis forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PK) in vitro and in vivo in the absence of DNA. The purified Artemis protein alone possesses single-strand specific 5′ to 3′ exonuclease activity. Upon complex formation, DNA-PKphosphorylates Artemis, and Artemis acquires endonucleolytic activity with respect to single-stranded nucleotides, including 5′ and 3′ overhangs, as well as hairpins. Further, the Artemis:DNA-PKcs complex can open hairpins generated by the RAG complex from a 12/23-substrate pair. Thus, DNA-PKregulates Artemis by both phosphorylation and complex formation to permit enzymatic activities that are critical for the hairpin opening step of V(D)J recombination and for all of the 5′ and 3′ overhang processing in nonhomologous DNA end joining.